Upgrade of 3 Tesla magnetic resonance imaging system

3特斯拉磁共振成像系统升级

• 批准号: 460922097
• 金额: --
• 依托单位: Technische Universität Dresden
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/460922097?language=en
• 关键词: Upgrade; Tesla; magnetic; resonance; imaging

Magnetic resonance imaging (MRI) is a key research tool in the cognitive neurosciences and is critical for developing an understanding of the human brain in both health and disease. MRI allows for non-invasive, whole-brain measurements that inform us about brain function as well as brain structure. The Neuroimaging Centre at the Technische Universität Dresden was established in 2006 when the currently used 3 Tesla MRI was commissioned. Over the last 14 years, this MRI machine has enabled research groups at the faculties of psychology and medicine to perform internationally competitive, cognitive neuroscience research. MRI is also the key measurement technique within several large-scale funding initiatives, such as two collaborative research centres (SFB 940 and TRR 265), and a wide range of individual project grants. Based on these ongoing funding initiatives, we will focus on the overarching research question of delineating the mechanism of cognitive control and volition, both in health and disease. In particular, using interlinked computational and experimental studies, we will establish a theoretical framework of how the brain dynamically exerts cognitive control and uses meta-control to rapidly adapt its action selection between different tasks and changing contexts. We will use this framework to develop mechanistic accounts of addictive behaviour, dysfunctional learning processes, the development of maladaptive habits and impaired cognitive control such as response inhibition failures and more generally failures in forward planning during action selection. The aim of this research program is to derive a mechanistic understanding of cognitive control, its failures in disease and to develop mechanism-based interventions for mental disorders.

磁共振成像（MRI）是认知神经科学中的关键研究工具，对于了解人类大脑的健康和疾病至关重要。MRI允许进行非侵入性的全脑测量，可以让我们了解大脑功能和大脑结构。德累斯顿工业大学的神经成像中心成立于2006年，当时正在使用的3特斯拉MRI被委托。在过去的14年里，这台MRI机器使心理学和医学系的研究小组能够进行具有国际竞争力的认知神经科学研究。MRI也是几个大规模资助计划中的关键测量技术，例如两个合作研究中心（SFB 940和TRR 265）以及广泛的个人项目赠款。基于这些正在进行的资助计划，我们将专注于描绘认知控制和意志的机制，无论是在健康和疾病的总体研究问题。特别是，使用相互关联的计算和实验研究，我们将建立一个理论框架，大脑如何动态地发挥认知控制，并使用元控制，以快速适应不同的任务和不断变化的环境之间的行动选择。我们将使用这个框架来开发成瘾行为，功能失调的学习过程，适应不良习惯的发展和受损的认知控制，如反应抑制失败，更普遍的失败，在行动选择过程中的前瞻性规划的机械帐户。该研究计划的目的是获得认知控制的机械理解，其在疾病中的失败，并制定基于机制的精神障碍干预措施。