Analysis of tick-encoded immunoregulatory serine proteinase inhibitors (serpins)

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Ticks are obligate ectoparasites that infest mammals, birds, repltiles, and amphibians and are found in many region of the world where they are the major vectors transmitting a great number of pathogens of human and animals. In Japan and other East Asian countries, Haemaphisalis longicornis, a tick commonly infesting cattle and dogs is a major vector of Theileria sergenti/buffeli, which are economically important disease of cattle. In the livestock industry ticks, the importance of ticks is their role as vectors of disease pathogens of livestock. Suppression of the tick vector population is considered as the method of choice in the absence of vaccines to target specific diseases transmitted by ticks. Several disadvantages associated with the use of acaricide which is the current method of choice to control ticks have necessitated the need to develop alternative methods for the tick control. Host immunization against ticks is one of the most promising method whose success is dependent o … More n the identification and characterization of tick vaccine candidatesSerpins may represent one of the most interesting target antigens for tick vaccine development because of their role in regulation of several physiological functions such as the blood clotting cascade, clot resolution, the inflammatory response and complement activation. In humans, dysfunctions or deficiencies of serpins have resulted in diseases. Given the critical role that serpins play in physiology of several organisms, we proposed that ticks are likely to use serpins to disrupt defensive host processes and therefore could be considered as potential candidates far anti-tick vaccines. We have previously characterized two tick salivary gland proteins whose recombinant products were effective against tick. The focus of our research is to characterize additional protective antigens which can be used in cocktail with our previously characterized antigens. Recently, we succeed to the molecular cloning of H. longicomis serpin gene and the recombinant protein suggest the possible use of the tick vaccine. Less