Microbubble evaluation by ultrasonic wave micro holography method and fabrication of functionality bubble

超声波微全息法微泡评价及功能性气泡的制作

• 批准号: 15360215
• 负责人: YAMAKOSHI Yoshiki
• 金额: $ 9.79万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15360215/
• 关键词: Self organization; Microbubble; Ultrasonic wave; Manipulation; Micro object; Bjerknes force; Radiation force; Drug delivery system; 微小気泡; 気泡コンプレックス; ホログラフィ; マイクロ ホログラフィ; ドラツグ デリバリ システム

The purpose of this research is development of a new bubble operation technology that uses the supersonic wave. In this research, for this, two techniques were developed. The first method is a method of evaluating the bubble of calling "Supersonic wave microholography method". In site characteristic of micro bubbles inside the ultrasonic wave can be evaluated by using this method. The second method is a new control method by the ultrasonic wave of the bubble movement. This method is based on self organization of micro bubbles under the ultrasonic wave. By this method, bi-layered bubble mass (Inner layer is seed bubbles and outer layer is target objects), which is considered as important dynamics in future drug/gene delivery system, is easily fabricated. The self organization of this bubble and the application of the micro object were examined in respect of the theory, the numerical analysis, and the experiments. It was shown that the developed trapping technology of micro object based on self organization of the bubble was useful method in order to trap the micro objects. It can make a special mention of having done three invitation lectures relate with this subject in 2004.

本研究的目的是开发一种利用超声波的新型气泡操作技术。在这项研究中，为此开发了两种技术。第一种方法是气泡的评价方法，称为“超声波显微全息法”。利用该方法可以评价超声波内部微气泡的现场特性。第二种方法是利用超声波对气泡运动进行控制的新方法。该方法基于超声波作用下微气泡的自组织。利用该方法，可以制备出内层为种子泡，外层为靶物的双层气泡质量，这是未来药物/基因传递系统中重要的动力学特性。从理论、数值分析和实验三个方面考察了气泡的自组织特性及其在微物体上的应用。结果表明，基于气泡自组织的微物体捕获技术是捕获微物体的有效方法。值得一提的是，我在2004年做了三次与这个主题相关的邀请讲座。

项目成果

N.Masuda, T.Tsujita, T.Ebuchi, Y.Yamakoshi: "Low-Frequency Elastic Wave Imaging by Adaptive Combination of Fundamental and Tissue Harmonic Ultrasonic Waves"Jpn.J.Appl.Phys.. 42. 3271-3275 (2003)

N.Masuda、T.Tsujita、T.Ebuchi、Y.Yamakoshi：“基于基波和组织谐波超声波的自适应组合的低频弹性波成像”Jpn.J.Appl.Phys.. 42. 3271-3275 (2003)

Low-Frequency Elastic Wave Imaging by Adaptive Combination of Fundamental and Tissue Harmonic Ultrasonic Waves

基波和组织谐波超声波自适应组合的低频弹性波成像

• 发表时间: 2003
• 期刊: Jpn.J.Appl.Phys. 42
• 作者: N.Masuda;T.Tsujita;T.Ebuchi;Y.Yamakoshi
• 通讯作者: Y.Yamakoshi

新たな超音波医用技術の開拓

开发新的超声医疗技术

• 期刊: 検査技術 (印刷中)
• 作者: Kawano;T.;Kato;Y.;Tani;R.;Takao;H.;Sawada;K.;Ishida M.;山越芳樹
• 通讯作者: 山越芳樹

Y.Yamakoshi: "Micro Bubble Aggregation by Interference of Incident and the Secondary Ultrasonic Waves and its Application to Buble Characterization"IEEE, International Symposium on Ultrasonics. 2003. 256-257 (2003)

Y.Yamakoshi：“通过入射和二次超声波的干扰进行微气泡聚集及其在气泡表征中的应用”IEEE，国际超声波研讨会。

山越芳樹: "超音波の物理的性質と医用応用"総合臨床. 第53巻1号. 17-22 (2004)

Yoshiki Yamakoshi：“超声的物理特性和医学应用”，第 53 卷，第 1. 17-22 期（2004 年）。