Control of self-organization of microbubbles by ultrasonicwave and progressing to the medical treatment and biotechnology

有效地将携带药物的溶液和基因导入细胞的药物和基因传递系统是未来医学治疗中很有前途的技术之一。然而，为了实现这一技术，需要三个基本的技术发展。分别是用于将药物或基因引入细胞的剂量改善技术、药物或基因载体的靶向诱捕技术、药物或基因载体内的控释技术。在本研究中，开发了气泡“组”控制技术，以开发用于未来药物输送系统的复杂方法。本研究的主要成果如下：1。提出了一种新的能够分析气泡群运动的数值模拟方法。在该模型中，考虑了相邻气泡的二次超声波对振荡气泡造成的辐射压力的集合，以及周围液体的粘度。提出了一种基于微泡的酵母细胞捕获技术。提出了一种利用气泡群的自组织特性操纵气泡的新技术。本研究获得的新发现和新技术将成为开发未来药物或基因传递系统的基础技术。

The drug and the gene delivery system that effectively introduces the carrying drug solution and the gene in the cell are one of promising technologies in the future medical treatment. However, in order to achieve this technology, three basic technological developments are required. They are, dose improvement technology, which is used for introducing the drug or gene in the cell, targeted trapping technology of drug or gene vehicles, and controlled release technology of drug or gene inside the vehicles. In this research, "Group" control technology of bubbles was developed in order to develop sophisticated methods used in the future drug delivery system. The result of this research is achieved as follows.1.It proposed a new numerical simulation method that was able to analyze the movement of the bubble group. In this model, the set of the radiation pressure to the oscillating bubble caused by the secondary ultrasonic wave from the neighboring bubbles, the viscosity of a surrounding liquid are considered.2.The trapping technology of the yeast cells, which is based on micro bubble, was proposed.3.A novel technology of bubble manipulation using the self-organization of the bubble group was developed.It is considered that the new findings and novel technologies obtained in this research become basic technologies in developing the future drug or gene delivery system.