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Ultrasonic wave micro manipulation of micro particle and its application on measurement

微小颗粒的超声波微操控及其在测量中的应用

基本信息

批准号：
11650416
负责人：
YAMAKOSHI Yoshiki
金额：
$ 2.3万
依托单位：
GUNMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11650416/
关键词：
Micro particle Micro bubble Ultrasonic wave Acoustic radiation force Manipulation Trapping Bjerknes force Acoustic Power マンピュレーション極微小粒子ドラッグ・デリバリ計測

项目摘要

When small particles such as gas filled micro bubbles flow into ultrasonic wave field, the micro particles interact with the ultrasonic waves and the bubbles produce aggregations to make large masses of bubbles. Those bubbles are trapped against the surrounding liquid flow by ultrasonic waves. In this research, the micro particles manipulation by ultrasonic waves are proposed and its application to high accuracy measurement is proposed. Main results of this research are as follows. 1) Numerical model which is able to simulate micro particle motion inside the ultrasonic wave fields is developed and the dynamics of small particles are examined numerically. This numerical model is based on fluid dynamics and is able to simulate precise movement of micro particles under ultrasonic waves. 2) Micro bubble trapping based on primary and secondary Bjerknes forces is proposed and its application in the field of drug delivery system is demonstrated. In this experiment, the mechanism of micro bubbles trapping by ultrasonic waves is discussed both theoretically and experimentally. The experiments are carried out using two different types of micro bubbles for the ultrasonic waves with ultrasonic wave frequency 5 MHz. The dynamics of micro bubbles inside ultrasonic wave field are observed using two different types of gas filled micro bubbles with mean diameter 20 micro meter and with mean diameter 1.3 micro meter. 3) Several small particle manipulation methods based on acoustic radiation forces are proposed and some applications in the field of high accuracy measurement are shown. These results give valuable knowledge and methods of micro particle manipulation by ultrasonic waves.

当充满气体的微气泡等小颗粒流入超声波场时，微小颗粒与超声波相互作用，气泡产生聚集，形成大质量的气泡。这些气泡被超声波捕获到周围的液流中。在这项研究中，提出了超声波操纵微粒及其在高精度测量中的应用。本研究的主要结果如下。 1）建立了能够模拟超声波场内微小颗粒运动的数值模型，并对小颗粒的动力学进行了数值研究。该数值模型基于流体动力学，能够模拟超声波下微粒的精确运动。 2)提出了基于初级和次级Bjerknes力的微气泡捕获方法，并论证了其在药物输送系统领域的应用。本实验从理论上和实验上探讨了超声波捕获微气泡的机理。实验采用两种不同类型的微气泡进行超声波，超声波频率为5 MHz。采用平均直径20微米和平均直径1.3微米两种不同类型的充气微气泡，观察了超声波场内微气泡的动态。 3)提出了几种基于声辐射力的小颗粒操纵方法，并展示了在高精度测量领域的一些应用。这些结果为超声波操纵微粒提供了宝贵的知识和方法。