Internal micro pump system by ultrasonic wave

内部超声波微型泵系统

• 批准号: 07650470
• 负责人: YAMAKOSHI Yoshiki
• 金额: $ 1.47万
• 依托单位: GUNMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07650470/
• 关键词: Ultrasonic wave; Micro pump; Radiation force; Micro particle; Standing wave; 音響放射圧; 微小粒子; マイクロ ポンプ

It is clinically important to give medical treatment for circulatory diseases such as arterial sclerosis and thrombosis.For this purpose, micro mechanisms which are based on micro actuator controlled by micro CPU have been proposed. However, it may be difficult to apply these mechanisms in living tissues, because there are many problems to be solved in these mechanisms. For example, safety to the living tissues and reliability are not clear. In our research which is supported by the grant-in-aid, micro mechanisms which are based on the use of ultrasonic waves and micro particles are proposed and are studied. For example, when the micro particles are suspended in the ultrasonic standing waves and the standing waves shift laterally by shanging the phase of an ultrasonic wave, the micro particles move in the same lateral direction. This may become a micro scraper in the living tissues. The drag delivery system may be also designed in the same manner if the micro particles are trapped by the ultrasonic standing wave. In order to design such micro mechanisms including micro pump, micro scraper and micro particle trapping system, the basic experiments are carried out by using mimic vessels and characteristics of theses methods are presented.

动脉硬化、血栓形成等循环系统疾病的治疗具有重要的临床意义。为此，提出了基于微CPU控制的微致动器的微机构。然而，这些机制在活体组织中的应用可能比较困难，因为在这些机制中有许多问题需要解决。例如，对活体组织的安全性和可靠性尚不清楚。在资助项目的支持下，我们提出并研究了基于超声波和微粒子的微观机理。例如，当微粒子悬浮在超声波驻波中，驻波通过改变超声波的相位而发生横向位移时，微粒子沿同一横向方向运动。这可能成为活组织中的微型刮刀。如果微颗粒被超声波驻波捕获，则阻力输送系统也可以以相同的方式设计。为了设计微泵、微刮板和微颗粒捕获系统等微机构，利用模拟容器进行了基础实验，并介绍了这些方法的特点。

项目成果

Y.Yamakoshi, et.al.: "Internal tissue displacement measurement based on ultrasonic wave Doppler signal digital detection" Ultrasonics. 12. 354-359 (1996)

Y.Yamakoshi 等人：“基于超声波多普勒信号数字检测的内部组织位移测量”超声波。

Y.Yamakoshi,et,al.: "Shear elastic measurement in vivo using ultrasonic imaging of internal forced low frequency vibration" Aconstical Imaging. 22. 293-298 (1996)

Y.Yamakoshi 等人：“使用内部受迫低频振动的超声成像进行体内剪切弹性测量”非视觉成像。

Y.Yamakoshi: "Measurement technique using ultrasonic radiation force to micro particle (in Japanese)" Japanese J.of Acoustical Society of Japan. 52,3. 210-216 (1996)

Y.Yamakoshi：“利用超声波辐射力对微粒进行测量的技术（日语）”日本声学学会杂志。

N. Shinozuka T Yamakoshi: "Transvaginal Sonographic Orientation Detection System using Ceramic Gyroscope" J. of Ultrasound in Med.15. 107-113 (1996)

N. Shinozuka T Yamakoshi：“使用陶瓷陀螺仪的经阴道超声方向检测系统”J. of Ultrasound in Med.15。

Y.Yamakoshi, et.al.: "Measurement of ultrasonic sound pressure from micro particle's locus observation insperiodically shifted ultrasonic standing wave (in Japanese)" Japanese J.of Acoustical Society of Japan. 52,1. 3-9 (1996)

Y.Yamakoshi 等人：“根据微粒轨迹观察不定期移动的超声波驻波测量超声波声压（日文）”日本声学学会杂志。