Ultrasonic wave assisted micro bubble manipulation and it application

超声波辅助微气泡操控及其应用

• 批准号: 13650454
• 负责人: YAMAKOSHI Yoshiki
• 金额: $ 2.3万
• 依托单位: Faculty of Engineering, Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13650454/
• 关键词: Ultrasonic waves; Micro bubbles; Radiation force; Bjerknes force; Trapping; Bubble manipulation; Ultrasonic contrast agent; 集合気泡; マニュピュレーション; 気泡集合; 操作

Micro air bubbles with a diameter of several micrometers or less attract attention in the field of a medical diagnosis and medical treatment. The research representative of this research is reporting the result in which it might inquire over the past several years about manipulation of the particle by the ultrasonic wave. In this research, the following results were obtained based on these results. 1) The evaluation of cellular dynamics which made full use of a simulation. 2) Detailed experimental examination containing from a basic experiment to an animal experiment. 3) Development of the new application based on these knowledge. The concrete results are follows. 1) About numerical analysis, the code in the 3-dimensional completeness model in consideration of the influence of the surface tension of a cellular film is completed. 2) It analyzed about nonlinear vibration of the air bubbles in the case where two or more air bubbles exist. The experimental system which can transmit four independent ultrasonic waves simultaneously based on a laboratory existing ultrasonic transmitting system was made. Examination about the influence erythrocyte affects cellular trapping, research of detailed cellular dynamics using the air bubbles were done.

直径为几微米或更小的微气泡在医学诊断和医学治疗领域中引起关注。该研究的研究代表报告了过去几年中可能询问的关于通过超声波操纵粒子的结果。在本研究中，基于这些结果获得了以下结果。1)其中细胞动力学的评价充分利用了模拟。2)详细的实验检查包括从基础实验到动物实验。3)基于这些知识开发新的应用程序。具体结果如下。1)在数值分析方面，完成了考虑细胞膜表面张力影响的三维完整性模型的程序。2)分析了两个或多个气泡存在时气泡的非线性振动。在实验室现有超声波发射系统的基础上，研制了能够同时发射四个独立超声波的实验系统。考察了红细胞对细胞捕获的影响，并利用气泡进行了详细的细胞动力学研究。

项目成果

Y.Yamakoshi, M.Koshiba, Y.Ozawa, N.Masuda: "Trapping of micro bubbles by ultrasnic waves"Jpn.J.Appl.Phys.. Vol.40. 1526-1527 (2001)

Y.Yamakoshi、M.Koshiba、Y.Ozawa、N.Masuda：“超声波捕获微气泡”Jpn.J.Appl.Phys.. Vol.40。

Masato Ida, Yoshiki Yamakoshi: "An Eulerian Scheme for Direct Numerical Simulation of Multibubble Dynamics in an Acoustic Field"Jpn.J.Appl.Phys.. Vol.40, No.5B. 3846-3851 (2001)

Masato Ida、Yoshiki Yamakoshi：“声场中多气泡动力学直接数值模拟的欧拉方案”Jpn.J.Appl.Phys.. Vol.40，No.5B。

山越芳樹: "超音波による微小気泡のハンドリング"日本音響学会誌. Vol.58,No.10. 659-662 (2002)

Yoshiki Yamakoshi：“使用超声波处理微泡”，日本声学学会杂志，第 58 卷，第 659-662 期（2002 年）。

山越芳樹: "超音波による微小気泡のハンドリング"日本音響学会誌. Vol.58 No.10. 659-662 (2002)

Yoshiki Yamakoshi：“使用超声波处理微泡”日本声学学会杂志第 58 卷第 659-662 期（2002 年）。

N.Chelly, Y.Yamakoshi, Y.Sawada, T.Sakamaku, M.Ida, N.Masuda, Y.Ozawa: "Effects of Red Cells on Ultrasonic Wave Micro bubble Trapping"Jpn.J.Appl.Phys.. Vol.41,No.5A. 3145-3146 (2002)

N.Chelly、Y.Yamakoshi、Y.Sawada、T.Sakamaku、M.Ida、N.Masuda、Y.Ozawa：“红细胞对超声波微气泡捕获的影响”Jpn.J.Appl.Phys.. Vol