Analysis of blood flow in brain under various tasks of extremities with functional MRI

“客观”功能磁共振成像（fMRI）图像具有无创性地可视化脑功能定位的优势，具有空间和时间分辨率。功能性核磁共振成像也显示，由于四肢的各种运动，血流明显增强。fMRI的图像对比描绘了脑内血氧血红蛋白水平依赖性的变化。我们试图通过手指的精确运动和动态血流的变化来研究慢性疼痛综合征中大脑血液循环的增强。“方法”(1)采用fMRI （1.5 T SIGNA LX， GE）观察5名健康志愿者的血流量增强（BOLD法），运动任务为拇指和手指的自愿对立运动。在fMRI上，反对任务重复进行10秒，然后休息10秒。采用spm96软件进行数据分析。(2)分析脊髓型颈椎病和纤维肌痛患者在运动任务和感觉刺激下脑血流量的变化。“结果”(1)对立运动激活了对侧感觉运动皮层。辅助运动区和运动前区被激活的强度也较小。(2)脊髓型颈椎病和纤维肌痛患者慢性和弥漫性疼痛影响脑部血液循环。上述发现说明了拇指和其他手指的相对运动对大脑血液循环的重要作用。功能磁共振成像是分析脑感觉运动区和评价康复效果的重要工具。

「objective」 Functional MRI (fMRI) image has a advantage to visualize the localization of brain function non-invasinely with spatial and temporal resolution. Functional MRI also shows a clear enhancement of blood flow by various motion of the extremities. The image contrast of fMRI depicts blood oxy-hemoglobin level dependent changes in brain. We tried to investigate the enhancement of blood circulation in brain by precise movements of fingers and the change of dynamic blood flow in the chronic pain syndrome.「Methods」 (1) Blood flow enhancement (BOLD method) was observed in five healthy volunteers using fMRI (1.5 T SIGNA LX, GE) with motion tasks of voluntary opposition movements of thumb and fingers. The task of opposition was preformed repeatedly for 10 seconds followed by 10 seconds-rest on fMRI. Data analysis was performed using SPM 96 software. (2)Change of blood flow in brain under motion task and sensory stimuli was analysed in patients with cervical spondylotic myelopathy and fibromyalgia.「Results」 (1) Brain activation was observed in the contralateral sensory-motor cortex by opposition movements. Supplementary motor area and pre-motor area were also activated with less intensity. (2) In spondylotic myelopathy and fibromyalgia patients, chronic and diffuse pain affected blood circulation in brain.「conclusions」 The finding mentioned above represents an important role of opposition movements of thumb and fingers for blood circulation in the brain. Functional MRI is a valuable tool to analyze the sensory-motor area of brain as well as to evaluate the effect of rehabilitation.