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Analysis of blood flow in brain under various tasks of extremities with functional MRI

功能性MRI分析四肢各种任务下的脑血流

基本信息

批准号：
15500394
负责人：
HIRASAWA Yasusuke
金额：
$ 1.34万
依托单位：
Meiji University of Oriental Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500394/
关键词：
functional MRI brain function oxy-hemoglobin precise movements fingers chronic pain

项目摘要

「objective」 Functional MRI (fMRI) image has a advantage to visualize the localization of brain function non-invasinely with spatial and temporal resolution. Functional MRI also shows a clear enhancement of blood flow by various motion of the extremities. The image contrast of fMRI depicts blood oxy-hemoglobin level dependent changes in brain. We tried to investigate the enhancement of blood circulation in brain by precise movements of fingers and the change of dynamic blood flow in the chronic pain syndrome.「Methods」 (1) Blood flow enhancement (BOLD method) was observed in five healthy volunteers using fMRI (1.5 T SIGNA LX, GE) with motion tasks of voluntary opposition movements of thumb and fingers. The task of opposition was preformed repeatedly for 10 seconds followed by 10 seconds-rest on fMRI. Data analysis was performed using SPM 96 software. (2)Change of blood flow in brain under motion task and sensory stimuli was analysed in patients with cervical spondylotic myelopathy and fibromyalgia.「Results」 (1) Brain activation was observed in the contralateral sensory-motor cortex by opposition movements. Supplementary motor area and pre-motor area were also activated with less intensity. (2) In spondylotic myelopathy and fibromyalgia patients, chronic and diffuse pain affected blood circulation in brain.「conclusions」 The finding mentioned above represents an important role of opposition movements of thumb and fingers for blood circulation in the brain. Functional MRI is a valuable tool to analyze the sensory-motor area of brain as well as to evaluate the effect of rehabilitation.

“客观”的功能磁共振成像（fMRI）图像具有空间和时间分辨率高、无创显示脑功能定位的优势。功能性磁共振成像还显示了四肢的各种运动明显增强了血流。功能磁共振成像的图像对比度反映了脑内血氧-血红蛋白水平依赖性的变化。本研究旨在探讨精确的手指运动对慢性疼痛综合征患者脑血流的促进作用及脑血流动力学的变化。“方法”（1）采用GE公司1.5T SIGNA LX型功能磁共振成像仪，对5名健康志愿者进行拇指和手指随意相对运动的运动任务，观察脑血流增强（BOLD法）。在fMRI上重复执行反对任务10秒，然后休息10秒。采用SPM 96软件进行数据分析。（2）分析脊髓型颈椎病和纤维肌痛患者在运动和感觉刺激下脑血流的变化。“结果”（1）反向运动可激活对侧感觉-运动皮层。辅助运动区和运动前区也被激活，但激活强度较低。(2)在脊髓型颈椎病和纤维肌痛患者中，慢性和弥漫性疼痛影响脑血液循环。“结论”上述发现表明拇指和手指的相对运动对大脑血液循环有重要作用。功能磁共振成像是分析脑感觉运动区和评价康复效果的重要工具。