Analysis of blood flow in brain under various tasks of extremities with functional MRI

“目的”功能磁共振成像(FMRI)图像具有时间和空间分辨率高、无创显示脑功能定位的优点。功能性核磁共振还显示肢体的各种运动使血流明显增强。功能磁共振成像的图像对比度描述了脑内血氧-血红蛋白水平的相关性变化。本研究旨在探讨慢性疼痛综合征患者手指精确运动对脑血流的增强作用及动态血流的变化。方法(1)采用1.5T SIGNA LX(GE)功能磁共振成像仪，对5名健康志愿者进行拇指、手指随意对位运动的血流增强(BOLD法)观察。反对任务被重复进行10秒，然后在fMRI上休息10秒。用SPM96软件进行数据分析。(2)分析脊髓型颈椎病和纤维肌痛患者在运动任务和感觉刺激下脑血流的变化。辅助运动区和运动前区也被激活，但强度较小。(2)脊髓型颈椎病和纤维肌痛患者中，慢性疼痛和弥漫性疼痛影响脑内血液循环。功能磁共振成像是分析大脑感觉运动区以及评估康复效果的有价值的工具。

「objective」 Functional MRI (fMRI) image has a advantage to visualize the localization of brain function non-invasinely with spatial and temporal resolution. Functional MRI also shows a clear enhancement of blood flow by various motion of the extremities. The image contrast of fMRI depicts blood oxy-hemoglobin level dependent changes in brain. We tried to investigate the enhancement of blood circulation in brain by precise movements of fingers and the change of dynamic blood flow in the chronic pain syndrome.「Methods」 (1) Blood flow enhancement (BOLD method) was observed in five healthy volunteers using fMRI (1.5 T SIGNA LX, GE) with motion tasks of voluntary opposition movements of thumb and fingers. The task of opposition was preformed repeatedly for 10 seconds followed by 10 seconds-rest on fMRI. Data analysis was performed using SPM 96 software. (2)Change of blood flow in brain under motion task and sensory stimuli was analysed in patients with cervical spondylotic myelopathy and fibromyalgia.「Results」 (1) Brain activation was observed in the contralateral sensory-motor cortex by opposition movements. Supplementary motor area and pre-motor area were also activated with less intensity. (2) In spondylotic myelopathy and fibromyalgia patients, chronic and diffuse pain affected blood circulation in brain.「conclusions」 The finding mentioned above represents an important role of opposition movements of thumb and fingers for blood circulation in the brain. Functional MRI is a valuable tool to analyze the sensory-motor area of brain as well as to evaluate the effect of rehabilitation.