Urologial Diseases in a Aging Society: From Genetic to Medical Csre (UroAgeCare)

老龄化社会中的泌尿系统疾病：从遗传到医学 Csre (UroAgeCare)

• 批准号: 464635516
• 负责人: Professor Dr. Roland Schüle
• 金额: --
• 依托单位: Arbeitsgruppe Hormone Dependent Cancer
• 依托单位国家: 德国
• 项目类别: Workshops for Early Career Investigators
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/464635516?language=en
• 关键词: Urologial; Diseases; Aging; Society; Genetic

High patient age and frailty are characterized by an inappropriate response to stress, that results in a higher frequency of adverse outcomes in benign and malignant disease. This ultimately leads to clinical scenarios where response to medical or surgical treatment may result in higher levels of mortality, institutionalization and disability. Information on the genetic, epigenetic and immunological background of this condition as compared to a standard patient population is scarce and still a matter of debate. Noteworthy, despite ongoing evolution of novel surgical and medical interventions in urology, selection criteria of clinical trials commonly result in an underestimation or exclusion of patients with high age or low performance status. Given the demographic development in Western countries, with increasing numbers of patients in advanced ages and with a growing number of comorbidities, a more profound analysis of the relevance of age and frailty is worthwhile. Urology represents the medical specialty that is most affected by the growing demographic of older adults as urological problems are by nature more common in elderly people, and care of patients aged 65 and older represents a large proportion of urologists’ practices. However, no explicit efforts on a research level, neither experimental nor translational, have been made till now in urology, so that we face a tremendeous deficite in our knowledge when taking care on elder patients in a clinical setting.To create a base for future more specific diagnostic and therapeutic approaches to urological conditions in this patient cohort, more in depth multidisciplinary research evaluating• the natural history and physiology of urological disease associated with age and frailty• specifics of the complex alterations in molecular biology, immunology, metabolism, and other age dependent factors contributing to responsiveness to medical or surgical treatment (i.e.pharmacogenetics, surgical outcome studies) • interaction with concurrent disease and their implications for the respective treatment• health-economic relevance of assessment and interventions in aged and frail patients under the aspect of providing information on quality-of-life-adjusted treatmentThe objective of the DFG-Nachwuchsakademie: Urological Diseases in an Ageing Society: From Genetics to Medical Care (UroAgeCare) is to integrate current cutting-edge knowledge from clinicians and researchers from diverse medical fields into an inter-professional faculty addressing all aspects of urological disease and care under the specific topic of age and frailty. Given the high expertise of the delineated faculty members, a selected group of young researchers will be able to generate high quality proposals, tailored for the individual project while opening additional reach beyond the field of urology.

高患者年龄和虚弱的特点是对压力的反应不适当，导致良性和恶性疾病不良结局的频率较高。这最终导致临床情况下，对医疗或手术治疗的反应可能导致更高水平的死亡率，机构和残疾。与标准患者人群相比，关于这种疾病的遗传、表观遗传和免疫学背景的信息很少，仍然是一个有争议的问题。值得注意的是，尽管泌尿外科的新型手术和药物干预正在不断发展，但临床试验的选择标准通常会导致低估或排除年龄较大或体力状态较低的患者。鉴于西方国家的人口发展，随着高龄患者数量的增加和合并症数量的增加，对年龄和虚弱的相关性进行更深入的分析是值得的。泌尿外科是受老年人人口增长影响最大的医学专业，因为泌尿系统问题在老年人中更常见，65岁及以上患者的护理占泌尿科医生实践的很大比例。然而，到目前为止，在泌尿外科领域还没有在研究水平上做出明确的努力，无论是实验性的还是转化性的，因此，当我们在临床环境中照顾老年患者时，我们的知识面临着巨大的缺陷。更深入的多学科研究评估·与年龄和虚弱相关的泌尿系统疾病的自然史和生理学·分子生物学，免疫学，代谢，以及其他与年龄有关的因素，这些因素会影响对内科或外科治疗的反应性（即药物遗传学，手术结果研究）·与并发疾病的相互作用及其对相应治疗的影响·健康-在提供生活质量调整治疗信息方面，评估和干预老年和体弱患者的经济相关性DFG-Nachwuchsakademie的目标：泌尿系统疾病在老龄化社会：从遗传学到医疗护理（泌尿系统护理）是整合目前的尖端知识，从临床医生和研究人员从不同的医学领域到跨专业的教师解决泌尿系统疾病和护理的各个方面下的年龄和脆弱的特定主题。鉴于指定教师的高度专业知识，选定的一组年轻研究人员将能够为单个项目量身定制高质量的提案，同时开辟泌尿外科领域以外的其他领域。