Inhibitory Background Field Hypothesis Generated by Gap Junction-Coupled Interneuron Systems in the Neocortex

新皮质间隙连接耦合中间神经元系统产生的抑制背景场假设

• 批准号: 16500188
• 负责人: FUJII Hiroshi
• 金额: $ 2.24万
• 依托单位: Kyoto Sangyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16500188/
• 关键词: gap junctions; spatio-temporal chaos in the brain; class I* neuron; transient synchrony; Milnor attractor; inhibitory interneuron system; dynamical systems-theoretic theory of memory; inhibitory background field; I*類ニューロンモデル; 過渡的同期・非同期現象; ニューロン系

The presence of multiple systems of inhibitory interneurons, densely coupled by gap junctions, i.e., electrical couplings, has been known. We studied possible dynamics of such GJ-coupled interneuron systems, and their functional roles in perception and cognition. We reported before that a system of "class I" neurons, with a particular nonlinearity, may exhibit extensive spatio-temporal chaos together with transient synchrony among neurons' spike firings. We give a mathematical characterization of the nonlinear structure of such a neuron class, and call them class I*. We studied the dynamics of such class I* systems, and showed the possibility that a non-classical attractor of Milnor type may control the whole dynamics.We argued that the phenomenon of transient synchrony, appeared in accordance with perceptual bindings in the real brain, could be explained as a phenomenon caused by the inhibitory background field organized by some GJ-coupled interneuron system(s), and which organizes th … More e pyramidal neuron system in relation to generations of functional cell assemblies and dynamic perceptual bindings.We presented also the dynamical systems-theoretic concept of memory based on the Milnor attractor, which may extend and found a basis of the concept of chaotic itinerancy in memory dynamics originally presented by I. Tsuda. As an application of our Milnor theory of memory in the brain, we presented a new hypothesis on the functional relevance of depolarizing GABA_A actions in cortical interneurons. In fact, although GABA is known as the principal mediator of inhibition, there exist numerous report that GABA may play an excitatory role under some conditions even after developmental period. We theorized that such "depolarizing" GABA actions may serve to temporarily invoke attractor-like memories when extensively activated by, e.g., top-down signals, while an ongoing background state of GABA changes its action to inhibition, returning the dynamical nature of the memory back to attractor ruins. Less

存在多种抑制性中间神经元系统，通过间隙连接紧密耦合，即电偶联，已经知道。我们研究了这种gj耦合的中间神经元系统的可能动力学，以及它们在感知和认知中的功能作用。我们之前报道了一类神经元系统，具有特殊的非线性，可能表现出广泛的时空混沌以及神经元脉冲之间的瞬态同步。我们给出了这类神经元的非线性结构的数学表征，并将其称为I*类。我们研究了这类I*系统的动力学，并证明了一个Milnor型的非经典吸引子控制整个动力学的可能性。我们认为，在真实大脑中出现的与感知绑定一致的瞬时同步现象，可以解释为由gj偶联的中间神经元系统组织的抑制背景场引起的现象，该背景场组织了与几代功能细胞集合和动态感知绑定相关的锥体神经元系统。我们还提出了基于Milnor吸引子的动态系统理论的记忆概念，这一概念可以扩展并为Tsuda最初提出的记忆动力学中的混沌流动概念提供基础。作为Milnor记忆理论在大脑中的应用，我们提出了一个关于GABA_A去极化作用在皮层中间神经元中的功能相关性的新假设。事实上，尽管GABA被认为是抑制的主要介质，但有大量报道称，在某些条件下，甚至在发育时期之后，GABA也可能发挥兴奋作用。我们的理论认为，这种“去极化”的GABA行为可能会在被自上而下的信号广泛激活时暂时唤起类似吸引子的记忆，而GABA的持续背景状态将其作用改变为抑制，使记忆的动态性质回到吸引子的破坏。少

项目成果

Prologue-The Work of the Late Professor Gen Matsumoto

序言-已故松本源教授的著作

• 发表时间: 2004
• 期刊: Journal of Integrative Neuroscience 3
• 作者: K.Aihara;I.Tsuda;H.Fujii
• 通讯作者: H.Fujii

Neocortical gap junction-coupled interneuron systems may induce chaotic behavior itinerant among quasi-attractors exhibiting transient synchrony

新皮质间隙连接耦合的中间神经元系统可能会在表现出瞬态同步的准吸引子之间诱导混沌行为

• 发表时间: 2004
• 期刊: Neurocomputing 58-60
• 作者: H.Fujii;I.Tsuda
• 通讯作者: I.Tsuda

A Complex Systems Approach to an Interpretation of Dynamic Brain Activity I : Chaotic itinerancy can provide a mathematical basis for information processing in cortical transitory and nonstationary dynamics

解释动态大脑活动的复杂系统方法 I：混沌行程可以为皮质瞬态和非平稳动力学中的信息处理提供数学基础

• 发表时间: 2004
• 期刊: Lecture Notes in Computer Science 3146
• 作者: I.Tsuda;H.Fujii
• 通讯作者: H.Fujii

フィードバック結合を持つネットワークにおける入力シグナルの伝播と保持

具有反馈耦合的网络中输入信号的传播和保留

• 发表时间: 2007
• 期刊: 物性研究 87
• 作者: 伊藤孝男;津田一郎
• 通讯作者: 津田一郎

Chaotic itinerancy in gap junction-coupled class I^* neurons

间隙连接耦合的 I^* 类神经元中的混沌游走

• 发表时间: 2006
• 期刊: Abstracts : The 8th RIES-Hokudai International Symposium on [bi]
• 作者: 羽二 生篤;鵜木 祐史;赤木 正人;M. Hatakeyama;Kazuhiro Matsumoto;I. Tsuda;Y. Fukushima;伊藤孝男;Y.Yamaguti;K.Matsumoto;S.Tadokoro
• 通讯作者: S.Tadokoro