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Effect of intra-articular injection of MCP-1 on arthritis

Effect of intra-articular injection of MCP-1 on arthritis
关节内注射MCP-1对关节炎的影响
批准号：
24790995
负责人：
FUJII Hiroshi
金额：
$2.75万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2012
资助国家：
日本
项目状态：
已结题
起止时间：
2012-04-01 至 2014-03-31
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790995/
关键词：
リウマチ学ケモカイン関節炎関節リウマチ

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英文摘要
Previously, we reported that ablation of an inflammatory chemokine receptor, CCR2, led to aggravation of the arthritis of IL-1ra-/- mouse. We assume that MCP-1, the ligand of CCR2, may resolve the arthritis in IL-1ra-/- and injected repeatedly 100pg of MCP-1 into the joint of IL-1ra-/- mouse. Unexpectedly, more severe arthritis was observed after injection of MCP-1, accompanying severe accumulation of neutrophils and macrophages into the joint. Multiplex analysis of cytokine levels in the joint of mature IL-1ra-/-CCR2-/-mouse (20-week-old) revealed decreased levels of regulatory cytokines, such as IL-4 and IL-10, indicating regulatory roles of macrophages during late stage of arthritis. Collectively, CCR2+ macrophages may serve as pro-inflammatory during early stage and later, as anti-inflammatory during late stage of arthritis.
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DOI： --
发表时间： 2014
期刊：
影响因子： --
作者： [藤井 博, 藤澤 雄平, 北田 欽也, 鈴木 康倫, 伊藤 清亮, 水島 伊知郎, 濱野 良子, 山田 和徳, 山岸 正和, 川野 充弘]
通讯作者： 川野 充弘
Studies on estimation method of key transcription factors by bioinformatics
Development of the crops diagnosis system using the newly developed digital camera
  • 批准号：
    26450016
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.24万
  • 财政年份：
    2014
  • 负责人：
    FUJII Hiroshi
  • 依托单位：
    Yamagata University
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Molecular Mechanism Controlling Reactivity and Selectivity of High-Valent Oxo-Metal Complexes
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