Functional analysis of fatty acid-binding proteins (FABPs) involved in nuclear receptor signaling

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(1) Functional analysis of FABP5 in nuclear receptor PPAR signaling in carcinogenesis or metastasis: I have found that nuclear receptor PPAR target gene, FABP5, is up-regulated in human malignant prostate cancer cellsand that is localized into the nucleus in a ligand (fatty acid)-dependent manner.(2)Functional analysis of FABP6 in nuclear receptor FXR signaling: I have identified novel miRNAs and their target genes that were activated by the FXR agonist. Furthermore, I have demonstrated that a variant protein for FABP6, called FABP6-L/IBABP-L, has exhibited anti-apoptotic activity in the presence of bile acid in colorectal cancer cells.(3) Activation mechanisms of FABP5 gene expression: I have found that DNA methylation status of FABP5 gene isolated from PC-3 is much more demethylated compared withthat of the gene from PNT-2.