Functional analysis of autophagy in T cells of healthy donors and SLE patients
Functional analysis of autophagy in T cells of healthy donors and SLE patients
批准号:
22790924
负责人:
FUJII Hiroshi
金额:
$1.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
We successfully developed the high thorough-put and high sensitive method to measure autophagic activity of human activated T cells on flow cytometry. Using this method, we analysed the functional significance of autophagy for stress by cell replication, drugs. We confirmed that autophagy had inhibitory effects on apoptotic cell death of activated T cells.
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レトロウィルスベクターシステムを用いた抗血管内皮細胞抗体対応自己抗原FLRT2の同定
利用逆转录病毒载体系统鉴定抗血管内皮细胞抗体对应的自身抗原FLRT2
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[白井剛志, 藤井博司, 中村恭平, 渡部龍, 田島結実, 高澤徳彦, 石井智徳, 張替秀郎]
通讯作者:
張替秀郎
顕著な脳炎を呈した中枢神経ループス患者における新規抗EphB2自己抗体の同定
患有严重脑炎的中枢神经系统狼疮患者中新型抗 EphB2 自身抗体的鉴定
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[白井剛志, 藤井博司, 中村恭平, 渡部龍, 田島結実, 高澤徳彦, 石井智徳, 張替秀郎]
通讯作者:
張替秀郎
フローサイトメトリーを用いたヒトプライマリT細胞におけるオートファジーの定量と機能解析
使用流式细胞术对人原代 T 细胞自噬进行定量和功能分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[渡部龍, 藤井博司, 白井剛志, 田島結実, 高澤徳彦, 石井智徳, 張替秀郎]
通讯作者:
張替秀郎
Retroviral vector system identified FLRT2 as a novel cell surface autoantigen against anti-endothelial cell antibody in systemic lupus erythematosus
逆转录病毒载体系统鉴定FLRT2是系统性红斑狼疮中抗内皮细胞抗体的新型细胞表面自身抗原
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[白井剛志、藤井博司, 他]
通讯作者:
他
Retroviral vector system identified FLRT2 as a novel cell surface autoantigen against anti-endothelial cell antibodies in systemic lupus erythematosus.
逆转录病毒载体系统将 FLRT2 鉴定为针对系统性红斑狼疮抗内皮细胞抗体的新型细胞表面自身抗原。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Shirai. T , Fujii. H, Ono. M, Takasawa. N , Ishii. T, Harigae. H.]
通讯作者:
Harigae. H.
共 6 条
Studies on estimation method of key transcription factors by bioinformatics
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批准号:16K14857
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2016
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负责人:FUJII Hiroshi
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依托单位:
Development of the crops diagnosis system using the newly developed digital camera
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批准号:26450016
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2014
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负责人:FUJII Hiroshi
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依托单位:
Effect of intra-articular injection of MCP-1 on arthritis
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批准号:24790995
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2012
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负责人:FUJII Hiroshi
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依托单位:
Development of genetic statistics verification base in effect of breeding based on allele analysis
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批准号:23580055
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.66万
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财政年份:2011
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负责人:FUJII Hiroshi
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依托单位:
Molecular Mechanism Controlling Reactivity and Selectivity of High-Valent Oxo-Metal Complexes
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批准号:22350030
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.4万
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财政年份:2010
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负责人:FUJII Hiroshi
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依托单位:
Top-down mechanisms of perception: dynamical-systems scenarios based on neurophysiology
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批准号:22500281
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.08万
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财政年份:2010
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负责人:FUJII Hiroshi
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依托单位:
Functional analysis of fatty acid-binding proteins (FABPs) involved in nuclear receptor signaling
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批准号:22570112
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.58万
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财政年份:2010
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负责人:FUJII Hiroshi
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依托单位:
Transitions between "internal states" in the brain viewed as quasi-attractors- A mathematical and neurodynamical approach
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批准号:19500259
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:FUJII Hiroshi
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依托单位:
Analysis of regulation of nuclear receptor-mediated signal transdidian by the ligand-specific transporters
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批准号:18570104
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.63万
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财政年份:2006
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负责人:FUJII Hiroshi
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依托单位:
Inhibitory Background Field Hypothesis Generated by Gap Junction-Coupled Interneuron Systems in the Neocortex
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批准号:16500188
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2004
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负责人:FUJII Hiroshi
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依托单位:
Synthesis and Characterization of High Valnet Reaction Intermediate of Non-Heme Iron Enzymes
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批准号:14340212
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.6万
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财政年份:2002
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负责人:FUJII Hiroshi
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依托单位:
Studies on Novel Nuclear Receptor-mediated Signal Transduction
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批准号:13680685
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:FUJII Hiroshi
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依托单位:
Functional Alteration of Myoglobin to Nitrite Reductase by Synthetic Heme and Protein Mutations
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批准号:12640549
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2000
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负责人:FUJII Hiroshi
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依托单位:
STUDY ON PHYSIOLOGICAL FUNCTION OF CHYMOTRYPSIN INHIBITORS IN BOMBYX MORI
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批准号:11306005
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$26.27万
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财政年份:1999
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负责人:FUJII Hiroshi
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依托单位:
Mathematical Study of the Dynamical Cell Assembly Hypothesis as the Encoding Principle of the Brain
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批准号:10640140
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1998
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负责人:FUJII Hiroshi
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依托单位:
Development of Anti-loosening Screw Fasteners
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批准号:10450064
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$3.07万
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财政年份:1998
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负责人:FUJII Hiroshi
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依托单位:
Integration of linkage map, RFLP map and chromosomal map
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批准号:09045069
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$4.03万
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财政年份:1997
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负责人:FUJII Hiroshi
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依托单位:
A Theoretical and Empirical Study on the Mechanism of BOJ's Market Operation
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批准号:09630095
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.09万
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财政年份:1997
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负责人:FUJII Hiroshi
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依托单位:
Studies on Genetic Resources of the silkworm, Bombyx mori
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批准号:08456037
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.99万
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财政年份:1996
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负责人:FUJII Hiroshi
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依托单位:
Mathematical Study of The Dynamical cell Assembly Hypothesis as the Encoding mechanism of the brain
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批准号:08640311
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
-
财政年份:1996
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负责人:FUJII Hiroshi
-
依托单位:
海外基金