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3-Dimension image of tumor vessel using monochromatic synchrotron radiation.

使用单色同步辐射的肿瘤血管 3 维图像。

基本信息

批准号：
17591303
负责人：
IMAI Shigeki
金额：
$ 2.11万
依托单位：
Kawasaki Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591303/
关键词：
synchrotron radiation ultra-high resolution CT SPring-8 tumor vessel 3-dimension image

项目摘要

Purpose: Our studies aimed to evaluate the structures of micro vessels in tumor using monochromatic X-ray 3D-CT.Materials and Methods: VX2 carcinomas were transplanted into the 50 auricles of rabbits, and randomize into 5 groups. To the first group, 12 hours after transplantation, we injected Ba-gelatine mixed emulsion into the auricular artery by hands. In the same way, to the second group we injected Ba-gelatine mixed emulsion 24 hours after injection, to the third 48 hours, to the fourth 72 hours, to the fifth after 7 days. First of all, we take two dimensional projections of the auricles using monochromatic x-ray, and select several auricles, had moderately consistency of vessels. Subsequently, 4 auricle were taken 3D-CT images. One is taken images in 3 different parameters to decide the adequate parameters. And, other 3 were take different period after injection to decide the adequate period after injection. Image analysis was done with Image-Pro Plus, TRI-3D VOL, and visually.Results: Because of a great number of images, reconstruction of images has not finished. So numerical analysis has not been archived. In visually, the images, in 5.83 um/pixel is obviously clear rather than in 12 um/pixel. There is no differentiation between the image by 20KeV and by 36KeV. And most adequate period to evaluate the vessels seems to be 72 hours after transplantation.Conclusion: The monochromatic X-ray 3D-CT system was a useful tool to evaluate the tumor microvessels. But to take images and to reconstruction images needs too much time.After this, we are going to analyze the images immediately.

目的：材料与方法：将VX 2肿瘤移植于50只兔耳廓，随机分为5组。第一组于移植后12小时，经耳动脉注入Ba-明胶混合乳剂。第二组于注射后24 h注射巴明胶混合乳剂，第三组于注射后48 h注射巴明胶混合乳剂，第四组于注射后72 h注射巴明胶混合乳剂，第五组于注射后7 d注射巴明胶混合乳剂。首先，我们用单色X线拍摄耳廓的二维投影，并选择几个耳廓，血管具有中等的一致性。随后，对4个耳廓进行3D-CT成像。一种是在3个不同的参数下拍摄图像，以确定适当的参数。另3例在注射后不同时间进行观察，以确定注射后的适宜时间.结果：由于图像数量较多，图像重建尚未完成。因此，数值分析尚未存档。在视觉上，5.83 um/pixel的图像明显清晰，而不是12 um/pixel。20 KeV和36 KeV的图像之间没有区别。结论：单色X线三维CT系统是评价肿瘤微血管的有效工具。但是图像的拍摄和重建需要很长的时间，在这之后，我们将立即对图像进行分析。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

高解像度放射光マイクロCTでの腫瘍標本の観察

高分辨率同步辐射显微CT观察肿瘤标本

DOI：
发表时间：
2005
期刊：
映像情報メディア学会誌 59・11
影响因子：
0
作者：
Sasaki M;et al.;Ehara S;Yoshioka Kunihiro;梅谷啓二
通讯作者：
梅谷啓二

Obsevation of tumor specimen using high resolution synchrotron radiation Micro-CT system.

使用高分辨率同步辐射Micro-CT系统观察肿瘤标本。

DOI：
发表时间：
2005
期刊：
THE JOURNAL OF THR INSTITUTE OF IMAGE INFORMATION AND TELEVISION ENGINEERS 59-11
影响因子：
0
作者：
Ehara S;Nishida J;et al.;Keiji Umetani
通讯作者：
Keiji Umetani

Evaluation of tris-acryl gelatin microsphere embolization with monochromatic x rays: Comparison with polyvinyl alcohol particles