The analysis of host factor on the progression in the patients with HCV.

宿主相关因素参与慢性丙型肝炎（HCV）的发展和干扰素治疗的有效性。细胞因子作为宿主因子是重要的，并且细胞因子产生的差异可能与细胞因子基因本身或调节细胞因子基因转录的基因的多态性有关。我们分析了60名健康受试者（对照）和112名HCV患者。根据肝活检和CT检查的纤维化程度分为5组。52例患者接受干扰素或干扰素与利伐比林联合治疗。对TNF-α启动子区-238、-308位点及α-Nco 1基因多态性进行了研究。并对IL-10启动子区-592、-819、-1082位点的多态性进行了研究。TNF-α启动子区-238、-308位点多态性在各组间无差异。在淋巴毒素-α Nco 1基因多态性位点上，F1患者B1/B1纯合子频率明显增高。IL-10基因多态性无差异。我们研究了多态性是否反映了干扰素治疗的有效性。持续应答者中，α-Nco 1基因多态性位点B2/B2纯合子的频率有降低的趋势。基因组分析可能有助于预测丙型肝炎感染的活动性和干扰素治疗的有效性。

Host-associated facors are involved in the development of chronic hepatitis C(HCV) and the efficiency of interferon therapy. Cytokine is important as a host factor, and differences in cytokine production may be related to polymorphisms in the cytokine genes themselves or genes, which regulate cytokine gene transcription. We analyzed 60 healthy subjects (control) and 112 HCV patients. The patients were divided into five groups according to fibrosis grade from liver biopsy (F classification) and CT scan. Fifty two patients received interferon or interferon and Rivabirin combined therapy. TNF-α promoter region at -238,-308,and lymphotoxin-α Nco1 polymorphism site were studied. Also, the polymorphisms of IL-10 promoter region at -592,-819,-1082 were studied. The polymorphisms of TNF-α promoter region at -238,-308 were no different among the groups. As for the lymphtoxin-α Nco1 polymorphism site, the frequency of B1/B1 homozygotes of F1 patients was significantly increased. The polymorphism of IL-10 showed no differences. We investigated whether polymorphism reflects the efficiency of interferon therapy. In the sustained responder, the frequency of B2/B2 homozygotes of lymphotoxin-α Nco1 polymorphism site tended to be lower. Genomic analyses might be useful for predicting the activity of hepatitis C infection and the efficiency of interferon therapy.