Significance of maspin tumor suppressor genes in human tumors

Maspin抑癌基因在人类肿瘤中的意义

基本信息

  • 批准号:
    16590290
  • 负责人:
  • 金额:
    $ 2.24万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2004
  • 资助国家:
    日本
  • 起止时间:
    2004 至 2005
  • 项目状态:
    已结题

项目摘要

Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation, but the biological significance of DNA hypomethylation in carcinogenesis is less understood. The expression of maspin (mammary serpin) in cancerous and non-cancerous tissues. Paradoxical maspin expression due to epigenetic modification has been addressed in several cancer cell types. To elucidate the role of the maspin gene in thyroid cancer, we studied methylation status in the promoter region and its expression in human cancers. Their methylation status evaluated by the methylation-specific PCR method showed a good inverse correlation with their immunoreactivity in surgically resected specimens. Our data suggest that over-expression of Maspin by DNA hypomethylation is closely associated with morphological dedifferentiation in thyroid cancers. Immunoreactivity for maspin was observed in metaplastic (intestinal metaplasia) and cancerous tissues. There aberrant expression were caused by the disruption of the epigenetic status at the promoter region. Aberrant maspin expression appears to be closely associated with morphological changes such as metaplasia, dysplasia and dedifferentiation, probably as a result of disruption of epigenetic expression mechanisms.
癌症相关的DNA低甲基化与癌症相关的高甲基化一样普遍,但DNA低甲基化在致癌过程中的生物学意义尚不清楚。乳腺丝状蛋白(乳腺丝状蛋白)在癌组织和非癌组织中的表达。由于表观遗传修饰的矛盾maspin表达已在几种癌细胞类型中得到解决。为了阐明maspin基因在甲状腺癌中的作用,我们研究了启动子区域的甲基化状态及其在人类癌症中的表达。通过甲基化特异性PCR方法评估的甲基化状态显示,它们在手术切除标本中的免疫反应性与甲基化状态呈良好的负相关。我们的数据表明,Maspin通过DNA低甲基化过度表达与甲状腺癌的形态去分化密切相关。在化生(肠化生)和癌组织中观察到maspin的免疫反应性。在启动子区域表观遗传状态的破坏引起了异常表达。maspin的异常表达似乎与皮化生、发育不良和去分化等形态学变化密切相关,可能是表观遗传表达机制被破坏的结果。

项目成果

期刊论文数量(76)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prevention of critical telomere shortening by oestradiol in human normal hepatic cultured cells and carbon tetrachloride induced rat liver fibrosis
  • DOI:
    10.1136/gut.2003.027516
  • 发表时间:
    2004-07-01
  • 期刊:
  • 影响因子:
    24.5
  • 作者:
    Sato, R;Maesawa, C;Masuda, T
  • 通讯作者:
    Masuda, T
Biacore's SPR technology for the development of telomere/telomerase-targeted theranips.
Biacore 的 SPR 技术用于开发端粒/端粒酶靶向疗法。
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Maesawa C;Oikawa K;Fujiwara-Akita H;Masuda T
  • 通讯作者:
    Masuda T
Acute Renal Failure Due to Leukemic Cell Infiltration Followed by Relapse at Multiple Extramedullary Sites in a Child with Acute Lymphoblastic Leukemia
  • DOI:
    10.1080/10428190310001593148
  • 发表时间:
    2004-04
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    A. Sato;M. Imaizumi;S. Chikaoka;H. Niizuma;Y. Hoshi;J. Takeyama;Kunihiro Fujii;Toshiyuki Nishio;Mika Watanabe;C. Maesawa;Y. Hayashi;K. Iinuma
  • 通讯作者:
    A. Sato;M. Imaizumi;S. Chikaoka;H. Niizuma;Y. Hoshi;J. Takeyama;Kunihiro Fujii;Toshiyuki Nishio;Mika Watanabe;C. Maesawa;Y. Hayashi;K. Iinuma
Short consensus probes with 3′-minor groove binder of the immunoglobulin heavy-chain gene for real-time quantitative PCR in B-cell non-Hodgkin lymphomas
  • DOI:
    10.1038/labinvest.3700092
  • 发表时间:
    2004-07-01
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Uchiyama, M;Maesawa, C;Masuda, T
  • 通讯作者:
    Masuda, T
Human PinX1, a potent telomerase inhibitor, is not involved in human gastrointestinal tract carcinoma.
  • DOI:
    10.3892/or.11.4.871
  • 发表时间:
    2004-04
  • 期刊:
  • 影响因子:
    4.2
  • 作者:
    Y. Akiyama;C. Maesawa;K. Wada;K. Fujisawa;T. Itabashi;Yoshinori Noda;T. Honda;N. Sato;K. Ishid
  • 通讯作者:
    Y. Akiyama;C. Maesawa;K. Wada;K. Fujisawa;T. Itabashi;Yoshinori Noda;T. Honda;N. Sato;K. Ishid
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MAESAWA Chihaya其他文献

MAESAWA Chihaya的其他文献

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{{ truncateString('MAESAWA Chihaya', 18)}}的其他基金

Development of high resolution imaging for tumor boundary delineation using 7-tesla magnetic resonance imaging enhanced by high iron diamine immersion
使用高铁二胺浸没增强的 7 特斯拉磁共振成像开发用于肿瘤边界描绘的高分辨率成像
  • 批准号:
    24659283
  • 财政年份:
    2012
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Studies for NACC1,a pluripotent transcriptional factor, in tumorcells
肿瘤细胞中多能转录因子 NACC1 的研究
  • 批准号:
    22390071
  • 财政年份:
    2010
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Alterations of microRNA associated with cancer-related genes
与癌症相关基因相关的 microRNA 的改变
  • 批准号:
    19590363
  • 财政年份:
    2007
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Analysis of constitutive epimutations of tumor-suppressor genes in normal cells for breast cancer risk assessment
正常细胞中抑癌基因的组成型表突变分析用于乳腺癌风险评估
  • 批准号:
    19K09063
  • 财政年份:
    2019
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    $ 2.24万
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Integrated functional analysis of the novel tumor suppressor genes OMD and PRELP, and their application to treatment of cancer
新型抑癌基因OMD和PRELP的综合功能分析及其在癌症治疗中的应用
  • 批准号:
    19H03429
  • 财政年份:
    2019
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Identification of Novel Hypermethylated Tumor Suppressor Genes Important in Breast Cancer Progression and Treatment Response
鉴定对乳腺癌进展和治疗反应重要的新型高甲基化肿瘤抑制基因
  • 批准号:
    372718
  • 财政年份:
    2017
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Operating Grants
De-repression of tumor suppressor genes by DNA-binding polyamides at hypermethylated CpG promoters
DNA 结合聚酰胺在高甲基化 CpG 启动子处消除肿瘤抑制基因的抑制
  • 批准号:
    9393114
  • 财政年份:
    2017
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    $ 2.24万
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Functions and regulations of tumor suppressor genes in vivo
体内抑癌基因的功能及调控
  • 批准号:
    17H01400
  • 财政年份:
    2017
  • 资助金额:
    $ 2.24万
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    Grant-in-Aid for Scientific Research (A)
Novel hypermethylated tumor suppressor genes as indicators of decitabine sensitivity in breast cancer
新型高甲基化肿瘤抑制基因作为乳腺癌地西他滨敏感性的指标
  • 批准号:
    365542
  • 财政年份:
    2016
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Studentship Programs
Identifying Hypermethylated Tumor Suppressor Genes in Breast Cancer with an in vivo Total Genome Knockdown Screen
通过体内全基因组敲除筛选鉴定乳腺癌中高甲基化的肿瘤抑制基因
  • 批准号:
    311429
  • 财政年份:
    2014
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    $ 2.24万
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The role of tumor suppressor genes in regulating cardiac tissue homeostasis.
肿瘤抑制基因在调节心脏组织稳态中的作用。
  • 批准号:
    294761
  • 财政年份:
    2013
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    $ 2.24万
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    Salary Programs
Functional analysis of tumor suppressor genes by generating gene-modified mice
通过生成基因修饰小鼠对抑癌基因进行功能分析
  • 批准号:
    24240120
  • 财政年份:
    2012
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    $ 2.24万
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    Grant-in-Aid for Scientific Research (A)
Identification of novel tumor-suppressor genes by Outlier approach
通过异常值方法鉴定新的肿瘤抑制基因
  • 批准号:
    23710227
  • 财政年份:
    2011
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
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