Involvement of the ventral premotor cortex in adaptive reaching movements following dynamic changes of motor frame of reference

运动参考系动态变化后腹侧前运动皮层参与适应性到达运动

• 批准号: 17500269
• 负责人: KURATA Kiyoshi
• 金额: $ 2.24万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17500269/
• 关键词: reaching; adaptation; neuronal activity; cerebral cortex; premotor cortex; reference frame; 視覚座標系; 運動座標系; 座標変換; 最適運動; 利得制御; 視覚運動変換; 運動学習

In reaching, a spatial visuomotor transformation should occur in our brain. We can make the transformation not only when the relationship between visual and motor coordinates is default, but also when a gain for the relationship is changed, for example, in a microsurgery. We trained monkeys to make reaching movements when visuospatially identical targets were presented on a computer display by aligning a cursor that indicated their hand position, while the gain was systematically changed. We recorded and analyzed movement-related neuronal activity in the ventral premotor cortex (PMv) and the primary motor cortex (MI) during reaction time. It was revealed that a majority of the MI neurons and a part of the PMv neurons showed activity changes depending on executed movement direction, amplitude, and velocity, whereas a number of the PMv neurons exhibited activity consistent to the visual location of the targets, but not to motor parameters such as amplitude and velocity. Furthermore, introcortical microstimulation in the PMv evoked changes in direction and amplitude (gain) of reaching movements. The results indicate that the PMv contributes to gain control of reaching during visuomotor transformation.

在触觉中，我们的大脑应该发生空间视觉运动转换。我们不仅可以在视觉和运动坐标之间的关系是默认的情况下进行转换，还可以在关系的增益改变时进行转换，例如在显微手术中。我们训练猴子，当视觉上相同的目标出现在计算机显示器上时，通过对齐指示它们手位置的光标，同时系统地改变增益，来做出伸展运动。我们记录并分析了反应时腹侧运动前皮质(PMV)和初级运动皮质(MI)的运动相关神经元活动。结果显示，大部分MI神经元和部分PMV神经元的活动随执行运动的方向、幅度和速度而变化，而部分PMV神经元的活动与目标的视觉位置一致，但与幅度和速度等运动参数无关。此外，皮质内微刺激PMV引起到达运动的方向和幅度(增益)的变化。结果表明，在视觉运动转换过程中，PMV有助于获得对到达的控制。

项目成果

大脳小脳連関

小脑小脑连接

• 发表时间: 2007
• 期刊: Brain Medical 19
• 作者: Izawa Y.;Sugiuchi Y.;Shinoda Y.;蔵田 潔
• 通讯作者: 蔵田 潔

運動制御の神経機構とその障害

运动控制的神经机制及其障碍

• 发表时间: 2005
• 期刊: 理学療法 22
• 作者: 黒川顕;他;蔵田 潔
• 通讯作者: 蔵田 潔

Gain control of visuomotor transformation in the ventral premotor cortex of monkeys.

控制猴子腹侧前运动皮层的视觉运动转化。

• 发表时间: 2006
• 期刊: Abstr. Jpn. Neurosci. Soc. 29(CD-ROM)
• 作者: Izawa Y.;Sugiuchi Y.;Shinoda Y.;蔵田 潔;Kiyoshi Kurata;Kiyoshi Kurata
• 通讯作者: Kiyoshi Kurata

The relationship between salivary biomarkers and State-Trait Anxiety Inventory score under mental arithmetic stress: A pilot study.

• DOI: 10.1213/01.ane.0000184196.60838.8d
• 发表时间: 2005-12-01
• 期刊: ANESTHESIA AND ANALGESIA
• 影响因子: 5.7
• 作者: Noto, Y;Sato, T;Hirota, K
• 通讯作者: Hirota, K

Cerebrocerebellar linkage.

脑小脑连接。

• 发表时间: 2007
• 期刊: Brain Medical 19
• 作者: Izawa Y.;Sugiuchi Y.;Shinoda Y.;蔵田 潔;Kiyoshi Kurata
• 通讯作者: Kiyoshi Kurata