Investigation of relationship between genomic aberrations in malignant meningioma and radio-sensitivity

恶性脑膜瘤基因组畸变与放射敏感性关系的研究

• 批准号: 17591526
• 负责人: ARAI Hiroshi
• 金额: $ 2.37万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591526/
• 关键词: malignant meningioma; radiation; genomic DNA microarray; DNA copy number; chromosome 14; chromosome 16; meningioma; ゲノムDNAマイクロアレイ; 放射線療法; DNAコピー数異常; CGH; genome DNA microarray

We detected the genomic aberrations in malignant meningioma (WHO grade II and III) using genomic DNA microarray (GenoSensor Array 300^<TM>), and discussed to the relationship between DNA copy number aberrations and influence of irradiation. Twelve malignant meningiomas were classified to two groups ; (1) tumors which showed growth after radiation therapy (Group R ; 5 cases), (2) tumors which did not received radiation therapy (Group NR ; 7 cases).Genomic aberrations which observed frequently in 12 malignant meningiomas were deletion of PRCKZ(1p36.33), D1S214(1p36.31), D6S311(6q1.3-q21), NF2(22q12.2), PDGFB(22q13.1). Deletion of DNA targets on chromosome 14q was observed in 2 of 7 cases in group R and 3 of 5 cases in group R. There was not significant difference, while there was difference in deletion area on chromosome. Deletion of DNA targets on chromosome 16q was observed in 5 of 7 cases in group R and 0 none of group NR. There was significant difference in two groups. It is suggested that there was relationship between loss of DNA copy number aberration on chromosome 14q, 16q and radiation therapy, but further investigations is necessary for define the association of gene alternation and radiation sensitivity.

我们应用基因组DNA芯片（GenoSensor Array 300^）检测了恶性脑膜瘤（WHO分级为II级和III级）的基因组畸变<TM>，并探讨了DNA拷贝数畸变与辐射影响的关系。将12例恶性脑膜瘤分为两组：（1）放射治疗后肿瘤生长R组5例;（2）未接受放射治疗的肿瘤（NR组; 12例恶性脑膜瘤中最常见的基因组异常为PRCKZ缺失（1p36.33）、D1S214（1p36.31）、D6S311（6q1.3-q21）、NF 2（22q12.2）、PDGFB（22q13.1）。R组7例中有2例出现14号染色体DNA靶点缺失，R组5例中有3例出现14号染色体DNA靶点缺失。染色体上的缺失区有差异，但差异不显著。R组7例中有5例出现16号染色体DNA靶点缺失，NR组0例未出现。两组比较有显著性差异。提示染色体14 q、16 q的DNA拷贝数丢失与放射治疗有关，但基因改变与放射敏感性的关系尚需进一步研究。

项目成果

Diffusion tensor imaging for preoperative evaluation of tumor grade in gliomas

• DOI: 10.1016/j.clineuro.2004.06.011
• 发表时间: 2005-04-01
• 期刊: CLINICAL NEUROLOGY AND NEUROSURGERY
• 影响因子: 1.9
• 作者: Inoue, T;Ogasawara, K;Kabasawa, H
• 通讯作者: Kabasawa, H

A case of ubfrontal Schwannoma

额叶神经鞘瘤一例

• 发表时间: 2005
• 期刊: Neurological Surgery 33・6
• 作者: Kashimura H.;Kashimura H.;Hiroshi Kashimura;Hiroshi Kashimura;Wada T.;Wada T.;Yoshitaka Kubo;Wada T.;Inoue T.;Komoribayasi N.
• 通讯作者: Komoribayasi N.

Three-dimensional anisotropy contrast imaging of pontine gliomas : 2 case reports.

脑桥胶质瘤的三维各向异性对比成像：2 例报告。

• 发表时间: 2007
• 期刊: Surg Neurol 67
• 作者: Kashimura H;Inoue T;Ogasawara K;Beppu T;Kanbara Y;Ogawa A.
• 通讯作者: Ogawa A.

Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma

• DOI: 10.1007/s10143-006-0019-7
• 发表时间: 2006-07-01
• 期刊: NEUROSURGICAL REVIEW
• 影响因子: 2.8
• 作者: Wada, T;Kuroda, K;Endo, S
• 通讯作者: Endo, S

A case of subfrontal schwannoma

额下神经鞘瘤一例

• 发表时间: 2005
• 期刊: Neurological Surgery 33(6)
• 作者: Kashimura H.;Kashimura H.;Hiroshi Kashimura;Hiroshi Kashimura;Wada T.;Wada T.;Yoshitaka Kubo;Wada T.;Inoue T.;Komoribayasi N.;Wada T.;Inoue T.;Komoribayasi N.;Komoribayasi N.
• 通讯作者: Komoribayasi N.