Epidemiologic studies on environmental and host-specific factors for human cancers

人类癌症的环境和宿主特异性因素的流行病学研究

• 批准号: 11181101
• 负责人: TAJIMA Kazuo
• 金额: $ 250.11万
• 依托单位: Aichi Cancer Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11181101/
• 关键词: Ethnoepidemiology; Cohort study; Case-control study; Molecular epidemiology; Clinical epidemiology; Cancer prevention; Risk factors; Protective factors; 分子疫学コーホート; 予防啓発; 広報活動; 遺伝子・環境交互作用; コホート研究; 宿主・環境交互作用; 宿主・環境要因; 国際比較研究; 大規模共同研究; 症例・対照

The priority area of the cancer epidemiology were formed by 4 study branches : 1) ethnoepidemiology ; analytical epidemiology ; 3) molecular epidemiology ; 4) clinical epidemiology. Furthermore, three promoting committees of large-scaled cohort study, molecular epidemiology and ATL research, supported the study programs in this area. The Japan Collaborative Cohort (JACC) study started from 1988 generated many new findings on risk and protective factors of Japanese cancer and these evidences were evaluated by seroepidemiological evidences. The committee of molecular epidemiology established a standard system for reservation of national and international human samples and effectual usage of these important materials. Furthermore its committee completed a standard manual for establishment of the Japanese Multi-institutional Collaborative Cohort (J-MICC) after deliberating all issues of ethical correspondence, standardization of questionnaire, collecting methods of blood samples, long-term reservation of human materials. The promoting committee of ATL research reviewed epidemiologic, basic and clinical studies conducted in the last 20 years and suggested several remaining and important subject. Available information obtained from this study area should be disseminated to prevent Japanese cancer, therefore, public symposia were organized twice a year in Tokyo and other cities from Hokkaido to Kyushu district. published useful information for cancer prevention Finally all information obtained from 25 planned subjects in five years were brought together into a couple of books entitled the forefront of cancer prevention" and also opened to the public by home page.

癌症流行病学的优先领域由4个分支组成：1)民族流行病学；分析流行病学；3)分子流行病学；4)临床流行病学。此外，大规模队列研究、分子流行病学和ATL研究三个促进委员会支持这一领域的研究计划。日本合作队列(JACC)研究始于1988年，在日本癌症的风险和保护因素方面产生了许多新的发现，并用血清流行病学证据对这些证据进行了评估。分子流行病学委员会建立了保存国家和国际人类样本和有效使用这些重要材料的标准系统。此外，其委员会在审议了伦理通信、问卷标准化、血样采集方法、长期保存人体材料等所有问题后，完成了建立日本多机构合作小组(J-MICC)标准手册。ATL研究促进委员会回顾了过去20年进行的流行病学、基础和临床研究，并提出了几个剩余的重要课题。应该传播从这个研究区域获得的现有信息，以预防日本癌症，因此，每年在东京和从北海道到九州区的其他城市举办两次公开研讨会。出版了对癌症预防有用的信息最后，从25个计划对象在五年内获得的所有信息都被汇集成几本名为《癌症预防的前沿》的书籍，并通过主页向公众开放。

项目成果

Hamajima,N.: "Polymerase chain reaction with two-pair primers for polymorphism genotyping"Jpn.J.Cancer Res.. 91. 865-868 (2000)

Hamajima，N.：“用于多态性基因分型的两对引物的聚合酶链式反应”Jpn.J.Cancer Res.. 91. 865-868 (2000)

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta.

• 发表时间: 2002
• 期刊: The EMBO journal
• 作者: M. Takekawa;K. Tatebayashi;F. Itoh;M. Adachi;K. Imai;H. Saito

HPC2/ELAC2 polymorphism associated with Japanese sporadic prostate cancer

• DOI: 10.1002/pros.20107
• 发表时间: 2004-11
• 期刊: The Prostate
• 作者: A. Yokomizo;H. Koga;N. Kinukawa;T. Tsukamoto;Y. Hirao;H. Akaza;M. Mori;S. Naito

Molecular mechanism for growth suppresiion of human hepatocellular carcinoma cells by acyclic retinoid.

无环类维生素A抑制人肝细胞癌细胞生长的分子机制。

• 发表时间: 2003
• 期刊: Carcinogenesis 24
• 作者: Matsushima-Nishiwaki;R.
• 通讯作者: R.

E1AF/PEA3 reduces the invasiveness of SiHa cervical cancer cells by activating serine proteinase inhibitor squamous cell carcinoma antigen.

E1AF/PEA3通过激活丝氨酸蛋白酶抑制剂鳞状细胞癌抗原来降低SiHa宫颈癌细胞的侵袭性。

• 发表时间: 2004
• 期刊: Exp.Cell Res. 299
• 作者: Iwasaki;M.
• 通讯作者: M.