Immunogenetic study on Mongoloids in Asian-Pacific and Polar areas
亚太和极地地区蒙古人种的免疫遗传学研究
基本信息
- 批准号:15256002
- 负责人:
- 金额:$ 13.15万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To clarify immunogenetic characteristics of Mongoloids in Asian Pacific regions from unique distribution of human T-cell leukemia virus(HTLV-I) and hepatitis B virus(HBV), the present international comparative study was conducted in the North Scandinavian and Northwestern Russian areas.1)In cooperation with epidemiologists of Osb University and Tromse University in Norway, we analyzed anti-HTLV-I antibodies of indigenous people in North Norway in 2003. We used 800 serum samples (400 Sami people and 400 non-Sami people) after getting official permission of Norway authorities and Sami community. All samples were collected 25 years ago for the other purposes and stored in the deep freezer in Oslo University. All samples were negative anti-HTLVI and we concluded that North Norway indigenous Sami people don't carry HTLV-I.2)In cooperation with Arkhangelsk University, we conducted field work targeting Nenezt people in Nariyan Mar, Nenets autonomous areas for three days in the end of 2004 We … More collected 10 ml blood samples from 109 subjects (patients of Central Clinics and general inhabitants) in Krasnoe town after getting informed consent from each subject. We separated buffy coat from plasma in the laboratory of the Central Clinics and carried back them to Arkhangelsk University. We analyzed antibodies of HTLV-I and we could not find a positive carrier. In terms of hepatitis viruses, we found 3 (2.8%) and 30 (28%) positives of anti-HCV and anti-HBVs. Among 30 anti-HBVs positives, there is no HBV antigen carrier and we could not confirm a genetic subtype of HBV in this population.From the present study including the previous studies held in Asian Continent, we could not confirm clustering of HTLV-I carriers among indigenous Mongoloids except Japanese in Japan archipelago. We need final studies on HTLV-I to clarify Mongoloids dispersal as to 1)confirmation of HTLV-I among Inuit people in the northeastern Greenland, and 2)investigation of HTLV-I among mummies 8,000-500 years old buried in Andes desert. Less
为了从人类T细胞白血病病毒(HTLV-I)和B肝炎病毒(HBV)的独特分布中阐明亚太地区蒙古人种的免疫遗传学特征,本研究在北欧和俄罗斯西北部地区进行了国际比较研究。2003年,我们分析了挪威北部土著人民的抗HTLV-I抗体。在获得挪威当局和萨米社区的正式许可后,我们使用了800份血清样本(400名萨米人和400名非萨米人)。所有样本都是25年前出于其他目的收集的,并储存在奥斯陆大学的深冻库中。所有样本的抗HTLVI抗体均为阴性,我们得出结论,挪威北部土著萨米人不携带HTLV-I。2)2004年底,我们与阿尔汉格尔斯克大学合作,针对涅涅茨自治区Nariyan Mar的涅涅茨人开展了为期三天的实地工作。 ...更多信息 在获得每名受试者的知情同意后,从Krasnoe镇的109名受试者(中心诊所的患者和普通居民)中采集10 ml血液样本。我们在中央诊所的实验室将血沉棕黄层与血浆分离,并将其带回阿尔汉格尔斯克大学。我们分析了HTLV-Ⅰ的抗体,没有发现阳性携带者。在肝炎病毒方面,我们发现抗-HCV和抗-HBV阳性分别为3例(2.8%)和30例(28%)。在30例抗-HBV阳性者中,没有HBV抗原携带者,我们不能确认该人群中HBV的遗传亚型。从本研究包括以前在亚洲大陆进行的研究中,我们不能确认在日本列岛的日本人以外的土著蒙古人中HTLV-I携带者的聚集性。我们需要对HTLV-I进行最后的研究,以澄清蒙古人的传播,以1)确认格陵兰东北部因纽特人中的HTLV-I,2)调查安第斯山脉沙漠中埋葬的8000 -500年前的木乃伊中的HTLV-I。少
项目成果
期刊论文数量(35)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:10.1
- 作者:A. Hishida;K. Matsuo;N. Hamajima;Hidemi Ito;M. Ogura;Y. Kagami;H. Taji;Y. Morishima;N. Emi;K. Tajima
- 通讯作者:A. Hishida;K. Matsuo;N. Hamajima;Hidemi Ito;M. Ogura;Y. Kagami;H. Taji;Y. Morishima;N. Emi;K. Tajima
Cancer mortality in Japan (1950-2000).
日本癌症死亡率(1950-2000 年)。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Kuroishi;T.
- 通讯作者:T.
Cancer mortality statistics in 30 ciountries (1953-1997).
30 个国家的癌症死亡率统计(1953-1997 年)。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Fukushima;K.;福島和彦(共著);Kuriki K.;Higashi N.;Senoo H.;Hanai S.;Sonoda J.;Chiba H.;Matsuo K.;Mizuno S.;Matsuo K.;Ito H.;Kuroishi T.;Kuroishi T.
- 通讯作者:Kuroishi T.
Lack of HTLV-I carriers in the Sami, an ethnic group living in the arctic area in Norway.
居住在挪威北极地区的萨米族人缺乏 HTLV-I 携带者。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Chiba;H.
- 通讯作者:H.
Immunohistological study on bovine, swine, and ovine skeletal muscle fibers for the localization of fatty acid translocase.
对牛、猪和绵羊骨骼肌纤维进行脂肪酸转位酶定位的免疫组织学研究。
- DOI:
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Fukushima;K.;福島和彦(共著);Kuriki K.;Higashi N.;Senoo H.;Hanai S.;Sonoda J.;Chiba H.;Matsuo K.;Mizuno S.;Matsuo K.;Ito H.;Kuroishi T.;Kuroishi T.;Banda T.
- 通讯作者:Banda T.
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TAJIMA Kazuo其他文献
TAJIMA Kazuo的其他文献
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{{ truncateString('TAJIMA Kazuo', 18)}}的其他基金
A Study of adaptation and authority, various book of this crape paper boos "JAPANESE FAIRY TALE SERIES".
改编和权威的研究,这本绉纸的各种书都嘘“日本童话系列”。
- 批准号:
22520188 - 财政年份:2010
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Immuno-genetics on Mongoloid in Pan-Pacific and Northland Areas
泛太平洋和北陆地区蒙古人种的免疫遗传学
- 批准号:
18406006 - 财政年份:2006
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
EP-DEMIOLOGICAL STUDY ONENVIRONMENTAL AND HOST-SPECIFIC FACT0RS FOR INCREASING CANCERS IN JAPAN, CHINA AND KOREA
日本、中国和韩国癌症发病率增加的环境和宿主特异性因素的流行病学研究
- 批准号:
17015052 - 财政年份:2005
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Epidemiologic studies on environmental and host-specific factors for human cancers
人类癌症的环境和宿主特异性因素的流行病学研究
- 批准号:
11181101 - 财政年份:1999
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Anthro-genetics on Paleomongoloid in Pan-Pacific and Northland Areas
泛太平洋和北陆地区古蒙古人种的人类遗传学
- 批准号:
11691226 - 财政年份:1999
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Anthropo-genetics on paleomongoloid in South America
南美洲古蒙古人种的人类遗传学
- 批准号:
09041195 - 财政年份:1997
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for international Scientific Research
The study of "OUJYODEN" at mediaval age on Japan
日本中世纪“王城电”研究
- 批准号:
07610432 - 财政年份:1995
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Anthropo-genetics on paleomongoloid in South America
南美洲古蒙古人种的人类遗传学
- 批准号:
07041171 - 财政年份:1995
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for international Scientific Research
Study on Higher Order Phase Transition of Phospholipid Bilayrs and Stability of Emulsion Formed with These Disperisons
磷脂双层的高阶相变及其分散体乳液的稳定性研究
- 批准号:
06453059 - 财政年份:1994
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
相似海外基金
Study on the protective factors for total mortality among HTLV-I carriers
HTLV-I携带者总死亡率的保护因素研究
- 批准号:
20K10506 - 财政年份:2020
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Establishment of a non-human primate model using cynomolgus monkeys for evaluating anti-HTLV-I mother to child infection drugs.
食蟹猴非人灵长类动物模型的建立,用于评价抗HTLV-I母婴感染药物。
- 批准号:
16K15285 - 财政年份:2016
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
How HTLV-I Tax and HBZ control telomerase activity to induce adult T-cell leukemia
HTLV-I Tax 和 HBZ 如何控制端粒酶活性以诱导成人 T 细胞白血病
- 批准号:
9513500 - 财政年份:2016
- 资助金额:
$ 13.15万 - 项目类别:
How HTLV-I Tax and HBZ control telomerase activity to induce adult T-cell leukemia
HTLV-I Tax 和 HBZ 如何控制端粒酶活性以诱导成人 T 细胞白血病
- 批准号:
9304181 - 财政年份:2016
- 资助金额:
$ 13.15万 - 项目类别:
Role of HTLV-I Tax-induced NF-kB in activation of ICN1 and immortalization of vir
HTLV-I Tax诱导的NF-kB在ICN1激活和vir永生化中的作用
- 批准号:
8435077 - 财政年份:2013
- 资助金额:
$ 13.15万 - 项目类别:
Role of HTLV-I Tax-induced NF-kB in activation of ICN1 and immortalization of vir
HTLV-I Tax诱导的NF-kB在ICN1激活和vir永生化中的作用
- 批准号:
8606171 - 财政年份:2013
- 资助金额:
$ 13.15万 - 项目类别:
Elucidation of mechanism for HTLV-I-associated Sjogren's syndrome
阐明 HTLV-I 相关干燥综合征的机制
- 批准号:
25461477 - 财政年份:2013
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The elucidation of the signalings of cytoskeletal reorganization involved in the development of HTLV-I-associated myelopathy
阐明参与 HTLV-I 相关脊髓病发生的细胞骨架重组信号
- 批准号:
24591267 - 财政年份:2012
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of HTLV-I-specific anti-cancer therapy by using single chain T cell receptors and single chain trimers of MHC-I.
利用单链T细胞受体和MHC-I单链三聚体开发HTLV-I特异性抗癌疗法。
- 批准号:
24590547 - 财政年份:2012
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mathematical epidemic models for the rapidly growing infection of HTLV-I
HTLV-I 感染迅速增长的数学流行病模型
- 批准号:
24540137 - 财政年份:2012
- 资助金额:
$ 13.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)