Anthropo-genetics on paleomongoloid in South America

为了明确日本人和安第斯人的古人类关系，比较了1)哥伦比亚、智利、玻利维亚和智利的安第斯人，2)秘鲁南部和智利北部的安第斯人木乃伊，3)日本南部的安第斯人木乃伊的人类t细胞白血病病毒I型（htlf -I）前病毒DNA、线粒体DNA和核DNA的特征。从htlc - i原病毒和人类白细胞抗原（HLA-DQ）特异性基因的DNA分析中，明确了安第斯人与日本南部有密切的亲缘关系，但亚马逊、奥里诺科河和巴塔哥尼亚的人与他们有很大的不同。刚刚从6具木乃伊（1500-1000年前）中鉴定出HLA-DQ和β蛋白的特异性基因，并且已经完成了对智利北部46具木乃伊（8000-500年前）线粒体DNA d -环区域的碱基分析。除了传统的考古学研究外，通过这些民族流行病学和免疫遗传学研究，将产生古安第斯人在历史上分散的新证据。

To clarify the paleoanthropological relationship between Japanese and Andeans, charactistics of provirus DNA of human T-cell leukemia virus type I (HTLV-I), mitochodrial DNA and nuclear DNA was compared among 1) Andeans in Colombia, Chile, Bolivia and Chile, 2) Andean mummies in south Peru and north Chile, and 3) southern Japanese. From DNA analysis of HTLV-I provirus and specific genes of human leukocyte antigen (HLA-DQ), it was clarified that Andeans are closely related to southern Japanese, but people in Amazone, Orinoco and Patagonia were very different from them. Specific genes of HLA-DQ and betaglobin was just identified from 6 mummies (1500-1000 years ago) and also base analysis of D-loop regeon of mitochondial DNA from 46 mummies (8000-500 years ago) in north Chile have been already completed. Through those ethnoepidemiological and immunogenetic studies in addition to traditional ancheological studies, a new evidence of historical dispersal of paleo-Andeans would be generated.