Microchemical Processes in Microchannels with Photo-functional Interfaces

集成各种化学和/或物理功能，如电极、催化剂或可控润湿性表面，是进一步开发微全分析系统（μTAS）或芯片实验室化学的一种有前途的方法。本研究的目的是利用功能性微通道晶片开发新颖的微化学制程。主要成果如下：1.通过优化微通道芯片制作工艺中的键合工艺，成功地将Au、Pt、Ag等金属电极和TiO_2等半导体电极集成在微通道中，且无漏液现象。此外，我们还成功地用二氧化硅或二氧化钛纳米粒子对通道表面进行了修饰.作为电极集成微通道芯片的分析应用，我们开发了电化学辅助热透镜显微光谱。非荧光分析物的电化学选择性超灵敏检测系统获得成功 关于我们 3.将电极集成微通道芯片应用于电化学合成如迈克尔加成反应，成功地提高了反应的电流效率和选择性.基于曲折电极结构诱导的交流电渗流，我们开发了一种新型的微混合器，它可以在ms时间尺度内实现溶液在微通道内的快速混合.微通道中的光功能接口被应用于微流体控制。利用螺苯并吡喃衍生物的光致变色性，构建了流动切换装置。利用二氧化钛纳米粒子-疏水分子修饰表面制备了多级拉普拉斯阀，并将其应用于微批操作系统和油水相分离系统.将二氧化钛薄膜与微通道相结合，开发了具有潜在可控性的微型光催化反应器。我们成功地优化了氧化还原组合光催化反应的光学产率，如从L-赖氨酸一步合成L-哌啶酸。少

Integration of various chemical and/or physical functions such as electrodes, catalysts, or controlled wettability surfaces is a promising approach for further development of micro total analysis system (μTAS) or lab-on-chip chemistry. The aim of this research is development of novel microchemical processes by using functional microchannel chips. Brief accomplishments are as follows.1. Through optimizing bonding procedures in fabrication processes of microchannel chips, we succeed in integration of metal electrodes such as Au, Pt, Ag, and so on, as well as semiconductor electrodes such as TiO_2 in the microchannels without solution leakage. Also, we succeed in modification of the channel surface with silica or titania nanoparticles.2. As an analytical application of the electrode integrated microchannel chip, we developed electrochemically assisted thermal lens microspectroscopy. Ultrasensitive detection system of non-fluorescent analytes with electrochemical selectivity was successful … More ly constructed.3. Applying the electrode integrated microchannel chip to electrochemical synthesis such as Michael additions, we succeeded in enhancing the current efficiency and selectivity of the reactions.4. We developed a novel micromixer based on AC electroosmotic flow induced with meandering electrode structure, which allowed fast mixing of solutions in microchannel in ms time scale.5. Photofunctional interfaces in the microchannel were applied to microfluid control. By using photochromism of spirobenzopyran derivatives, flow-switching device was constructed. Titania nanoparticles-hydrophobic molecules modifying surfaces were used to prepare multistep Laplace valves, which were applied to construct micro batch operation system and oil-water phase separation system.6. Potential controllable micro photocatalytic reactors were developed by integration of titania film with microchannels. We succeeded in optimization of optical yield of redox-combined photocatalytic reactions such as one-step synthesis of L-pipecolinic acid from L-Lys by applied potential. Less