Regulation of cell proliferation and cell death by stress signaling in cancer
Regulation of cell proliferation and cell death by stress signaling in cancer
批准号:
17014013
负责人:
ICHIJO Hidenori
金额:
$35.2万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
This study aimed at analyzing the mechanisms by which cancer cells acquire abnormal proliferation and death-resistant phenotypes in the context of perturbation of stress signaling. By using ASK family knockout mice, we found that stress-activated MAP kinases play pivotal roles in development and expansion of human cancer.
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DOI:
10.1016/j.neures.2009.12.003
发表时间:
2010-03-01
期刊:
NEUROSCIENCE RESEARCH
影响因子:
2.9
作者:
[Kumakura, Karen, Nomura, Hiroshi, Matsuki, Norio]
通讯作者:
Matsuki, Norio
DOI:
10.1002/jcp.20465
发表时间:
2006-02-01
期刊:
JOURNAL OF CELLULAR PHYSIOLOGY
影响因子:
5.6
作者:
[Mizumura, K, Takeda, K, Ichijo, H]
通讯作者:
Ichijo, H
Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage
细胞外 ATP 诱导巨噬细胞凋亡需要活性氧依赖的 ASK1-p38 MAP 激酶途径激活
DOI:
--
发表时间:
2008
期刊:
J. Biol. Chem 283
影响因子:
--
作者:
[Noguchi, T., et. al.]
通讯作者:
et. al.
Serine 58 of 14-3-3{zeta} is a molecular switch regulating ASK1 and oxidant stress-induced cell death
14-3-3{zeta} 的丝氨酸 58 是调节 ASK1 和氧化应激诱导的细胞死亡的分子开关
DOI:
--
发表时间:
2009
期刊:
Mol.Cell.Biol. 29
影响因子:
--
作者:
[Zhou, J., et al.]
通讯作者:
et al.
Signaling pathways in invertebrate immune and stress response
无脊椎动物免疫和应激反应中的信号通路
DOI:
--
发表时间:
2009
期刊:
Invertebrate Survival Journal 6
影响因子:
--
作者:
[Hatanaka, R., et al.]
通讯作者:
et al.
共 77 条
Post-translational modifications of a mitochondria-resident protein and its role in systemic regulation
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批准号:16K15115
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2016
-
负责人:ICHIJO Hidenori
-
依托单位:
Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development
-
批准号:25221302
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$136.95万
-
财政年份:2013
-
负责人:ICHIJO Hidenori
-
依托单位:
A novel purification method for endogenous protein using ASKA technique
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批准号:25650061
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.66万
-
财政年份:2013
-
负责人:ICHIJO Hidenori
-
依托单位:
Involvement of lipid-metabolizing enzymes in stress response
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批准号:23659033
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:ICHIJO Hidenori
-
依托单位:
Drug development by the molecular mechanism-based analysis of stress signaling
-
批准号:20229004
-
项目类别:Grant-in-Aid for Scientific Research (S)
-
资助金额:$133.45万
-
财政年份:2008
-
负责人:ICHIJO Hidenori
-
依托单位:
Regulatory mechanisms of mucosal immunity by the ASK family signals
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批准号:18209055
-
项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.87万
-
财政年份:2006
-
负责人:ICHIJO Hidenori
-
依托单位:
Comprehension and application of biological information system based on the analysis of molecular mechanisms of stress response
-
批准号:13854022
-
项目类别:Grant-in-Aid for Scientific Research (S)
-
资助金额:$78.79万
-
财政年份:2001
-
负责人:ICHIJO Hidenori
-
依托单位:
Analysis of the Roles for Stress-activated MAP kinases in Oral Muco-epithelium
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批准号:12470396
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.3万
-
财政年份:2000
-
负责人:ICHIJO Hidenori
-
依托单位:
Analysis of ASK1 and ASK2 as stress signaling intermediates.
-
批准号:10470396
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.0万
-
财政年份:1998
-
负责人:ICHIJO Hidenori
-
依托单位:
Mechanisms of programd cell death and morphogenesis in cranio-facial development.
-
批准号:09557141
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.04万
-
财政年份:1997
-
负责人:ICHIJO Hidenori
-
依托单位:
STUDY FOR INTRACELLULAR SIGNAL TRANSDUCTION MECHANISM OF TGF-beta SUPERFAMILY.
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批准号:08457495
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.03万
-
财政年份:1996
-
负责人:ICHIJO Hidenori
-
依托单位:
海外基金