Development of new strategy for detection of disease denes

开发检测病灶的新策略

• 批准号: 17019063
• 负责人: INOKO Hidetoshi
• 金额: $ 100.29万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17019063/
• 关键词: 相関解析; マイクロサテライト; 多因子疾患; 同祖性; 連鎖解析; 酵母ツーハイブリッド; ネットワーク; ゲノム創薬; 関節リウマチ; 糖尿病; 酵母ツーハイブリッド法; ネットワーク解析; 蛋白相互作用; 関連解析; ゲノムワイド; 機能解析; 疾患モデルマウス; 酵母two hvbrid法; タンパク相互作用; GWAS; 尋常性乾鮮; NFKB alternative pathway; 破骨細胞; 遺伝疫学; 遺伝的荷重; NFkB altern

In order to identify susceptible gene for multi-factorial disease such as common disease, we have developed two methods, GWAS (genome-wide association study) using 30,000 microsatellites and detection of linkage between a trait and a marker in a random mating population without pedigree record. Utilizing these new methods, we could identify more than 30 disease susceptible genes. Towards genome-based drug discovery based on these disease genes, we have developed in silico network analysis and new yeast two hybrid system.

为了确定多因素疾病（如常见病）的易感基因，我们开发了两种方法，使用30，000个微卫星的全基因组关联研究（GWAS）和在无系谱记录的随机交配群体中检测性状与标记之间的连锁。利用这些新方法，我们可以鉴定出30多个疾病易感基因。针对基于这些疾病基因的基因组药物发现，我们开发了计算机网络分析和新的酵母双杂交系统。

项目成果

Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease

• DOI: 10.1007/s00439-009-0698-6
• 发表时间: 2009-10-01
• 期刊: HUMAN GENETICS
• 影响因子: 5.3
• 作者: Hinohara, Kunihiko;Nakajima, Toshiaki;Kimura, Akinori
• 通讯作者: Kimura, Akinori

Serotonin transporter gene promoter polymorphism and autism: A family-based genetic association study in Japanese population

• DOI: 10.1016/j.braindev.2005.09.003
• 发表时间: 2006-05
• 期刊: Brain and Development
• 影响因子: 1.7
• 作者: Shinko Koishi;Kenji Yamamoto;H. Matsumoto;S. Koishi;Youichi Enseki;Akitoshi Oya;Arata Asakura;Yutaka Aoki;Mariko Atsumi;T. Iga;Jyoji Inomata;H. Inoko;Tsukasa Sasaki;E. Nanba;N. Kato;T. Ishii;K. Yamazaki

Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.

• DOI: 10.2147/opth.s4727
• 发表时间: 2009
• 期刊: Clinical ophthalmology (Auckland, N.Z.)
• 作者: Kamio M;Meguro A;Ota M;Nomura N;Kashiwagi K;Mabuchi F;Iijima H;Kawase K;Yamamoto T;Nakamura M;Negi A;Sagara T;Nishida T;Inatani M;Tanihara H;Aihara M;Araie M;Fukuchi T;Abe H;Higashide T;Sugiyama K;Kanamoto T;Kiuchi Y;Iwase A;Ohno S;Inoko H;Mizuki N
• 通讯作者: Mizuki N

Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen

• DOI: 10.1182/blood-2007-02-075911
• 发表时间: 2007-08-01
• 期刊: BLOOD
• 影响因子: 20.3
• 作者: Kawase, Takakazu;Akatsuka, Yoshiki;Takahashi, Toshitada
• 通讯作者: Takahashi, Toshitada

Effects of a new immunosuppressive agent, beta-SQAG9, in swine kidney transplantation.

新型免疫抑制剂 β-SQAG9 在猪肾移植中的作用。

• 发表时间: 2007
• 期刊: Transpl Immunol 18
• 作者: Tanaka;T.;Sato;N.;他15名、16番目
• 通讯作者: 他15名、16番目