Risk assessment of cancer using telomere G-tail length measurement

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We have previously developed the assay to measure the G-tail length, so-called G-tail telomere hybridization protection assay (HPA). We also developed the kit and the high-throughput automated machine for G-tail measurement. We applied these technologies for not only basic research but also for the clinical research, and found that peripheral blood from gastrointestinal cancer patients exhibited significant shorter average G-tail lengths than non-cancerous control group. Whereas total telomere length also reduced in cancer patients, G-tail lengths are markedly reduced in gastrointestinal cancer patients. These findings suggest that G-tail length can be a useful marker for the cancer risk assessment.