Liver transplantation with novel strategy using the engineered chimeric liver as alternative graft

使用工程嵌合肝作为替代移植物的新策略肝移植

• 批准号: 20249058
• 负责人: UEMOTO Shinji
• 金额: $ 16.47万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20249058/
• 关键词: 移植外科学; 肝臓移植; キメラ肝臓

To solve the serious shortage of liver grafts, the feasibility of chimeric liver as an alternative liver graft has been investigated. The chimeric liver formed with rat hepatic parenchyma and mouse non-parenchyma was harvested from scaffold mouse and transplanted into rat recipient, followed by the immunosuppressive protocols. We have found, with appropriate immunosuppression, graft survival was significantly prolonged and graft tissues were maintained better. Moreover, we found its albumin production for 4 months. We have shown the possibility of the strategy using chimeric liver graft.

为了解决肝移植严重短缺的问题，人们开始研究嵌合肝作为替代肝移植的可行性。从支架小鼠身上取下大鼠肝实质与小鼠非实质形成的嵌合肝脏，按照免疫抑制方案移植到大鼠受体体内。我们发现，在适当的免疫抑制下，移植物存活时间明显延长，移植物组织维持得更好。此外，我们发现它的白蛋白产量为4个月。我们已经用嵌合肝移植证明了这种策略的可能性。

项目成果

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Replacement of the vascular endothelium in the mouse liver by the xenogeneic bone-marrow cells derived from the rat.

用源自大鼠的异种骨髓细胞替代小鼠肝脏中的血管内皮。

• 发表时间: 2010
• 作者: K.Jobara;T.Hata;S.Uemoto;et al.
• 通讯作者: et al.

Development of regerated chimeric liver grafts in mouse and rat combination and long-term evaluation of their potential after auxiliary transplantation.

小鼠和大鼠组合中再生嵌合肝移植物的开发及其辅助移植后潜力的长期评估。

• 发表时间: 2009
• 作者: 畑俊行;小林英司;上本伸二;et al.
• 通讯作者: et al.

Transplantation of chimeric liver with autologous hepatocyte and xenobiotic scaffold in mouse and rat combination

小鼠和大鼠组合自体肝细胞和异生支架的嵌合肝移植

• 发表时间: 2008
• 作者: Toshiyuki Hata;Shinji Uemoto;Eiji Kobayashi
• 通讯作者: Eiji Kobayashi

Auxiliary Transplantation of the chimeric liver graft in mouse and rat combination and evaluation of the long-term survival and proliferative capacity of the transplanted graft in the recipient rat.

小鼠和大鼠组合中嵌合肝移植物的辅助移植以及移植物在受体大鼠体内的长期存活和增殖能力的评估。

• 发表时间: 2010
• 作者: 畑俊行;小林英司;上本伸二;et al.
• 通讯作者: et al.