Liver transplantation with novel strategy using the engineered chimeric liver as alternative graft

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To solve the serious shortage of liver grafts, the feasibility of chimeric liver as an alternative liver graft has been investigated. The chimeric liver formed with rat hepatic parenchyma and mouse non-parenchyma was harvested from scaffold mouse and transplanted into rat recipient, followed by the immunosuppressive protocols. We have found, with appropriate immunosuppression, graft survival was significantly prolonged and graft tissues were maintained better. Moreover, we found its albumin production for 4 months. We have shown the possibility of the strategy using chimeric liver graft.