Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential

铁是生命所必需的，但铁超载是一种潜在的致命疾病。人类没有自然的机制来排泄铁，所以患有铁超载障碍的患者被用螯合剂Desferal治疗，以使铁的排泄通常从很小的时候就开始。地塞米松口服无效，必须皮下注射(12-24小时，5-6天/周)，导致患者依从性差。我们将使用我们实验室确定的一系列新的潜在口服活性铁络合剂进行关键的化学和生物实验。该项目的结果将对这些化合物作为药物的开发至关重要。

Iron is essential for life, but iron-overload is a potentially fatal condition. There is no natural mechanism to excrete iron in humans, so patients suffering from iron-overload disorders are treated with the chelator Desferal to enable iron excretion typically from an early age. Desferal is orally ineffective and must be given by subcutaneous infusion (12-24h, 5-6 days/week) resulting in poor patient compliance. We will conduct critical chemical and biological experiments with a new series of potentially orally active iron chelators identified in our lab. The results from this project will be vital for the development of these compounds as pharmaceuticals.