The fate of copper in atom transfer radical reactions

铜在原子转移自由基反应中的命运

• 批准号: DP150104672
• 负责人: Prof Paul Bernhardt
• 金额: $ 21.27万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104672
• 关键词: fate; copper; atom; transfer; radical

Copper (Cu) complexes of poly-amine ligands have emerged as extremely active homogeneous catalysts in atom transfer radical reactions, forming organic radicals from alkyl halide precursors, and they are now employed extensively in polymer and organic chemistry. The catalyst cycles between its Cu(I) and Cu(II) oxidation states reversibly yet both forms are susceptible to side reactions, particularly with solvents which can lead to loss of catalytic activity. This project aims to apply a multifaceted approach to interrogate the catalysts in both their Cu(I) and Cu(II) oxidation states and identify for the first time the pathways that lead to undesirable side reactions and provide new ways of optimising catalyst performance.

多胺配体的铜配合物作为极具活性的均相催化剂，在原子转移自由基反应中由烷基卤化物前体形成有机自由基，目前在聚合物和有机化学中得到广泛应用。催化剂在Cu(I)和Cu（II）氧化态之间可逆循环，但两种形式都容易发生副反应，特别是与溶剂的反应会导致催化活性的丧失。该项目旨在应用多方面的方法来询问Cu(I)和Cu（II）氧化态的催化剂，并首次确定导致不良副反应的途径，并提供优化催化剂性能的新方法。