Molybdenum enzyme electrochemical communication

钼酶电化学通讯

• 批准号: DP190103158
• 负责人: Prof Paul Bernhardt
• 金额: $ 24.65万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-02-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103158
• 关键词: Molybdenum; enzyme; electrochemical; communication

This project aims to understand the activity of three novel, but related, molybdenum enzymes, human mARC and its bacterial homologs YcbX and YiiM. The role of mARC in humans remains unknown twelve years after its discovery. All three enzymes catalyse the reduction of potentially harmful N-hydroxylated compounds and there is interest in this area from the perspective of drug design. This project will apply an electrochemical methodology to rapidly identify enzyme substrates and inhibitors. Molybdenum enzymes pervade all life forms and the outcomes of this research include a unified understanding of an emerging enzyme class involved in drug metabolism.

本项目旨在了解三种新的但相关的钼酶，人MARC及其细菌同源物YcbX和YIIM的活性。在MARC被发现12年后，它在人类中的作用仍然未知。这三种酶都催化还原潜在有害的N-羟基化化合物，从药物设计的角度来看，这一领域引起了人们的兴趣。该项目将应用一种电化学方法来快速识别酶底物和抑制剂。钼酶普遍存在于所有生命形式中，这项研究的结果包括对参与药物代谢的一种新兴酶类有统一的认识。