Molybdenum enzyme electrochemical communication

钼酶电化学通讯

• 批准号: DP190103158
• 负责人: Prof Paul Bernhardt
• 金额: $ 24.65万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-02-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103158
• 关键词: Molybdenum; enzyme; electrochemical; communication

This project aims to understand the activity of three novel, but related, molybdenum enzymes, human mARC and its bacterial homologs YcbX and YiiM. The role of mARC in humans remains unknown twelve years after its discovery. All three enzymes catalyse the reduction of potentially harmful N-hydroxylated compounds and there is interest in this area from the perspective of drug design. This project will apply an electrochemical methodology to rapidly identify enzyme substrates and inhibitors. Molybdenum enzymes pervade all life forms and the outcomes of this research include a unified understanding of an emerging enzyme class involved in drug metabolism.

该项目旨在了解三种新型但相关的钼酶，人类mARC及其细菌同系物YcbX和YiiM的活性。mARC在人类中的作用在发现12年后仍然未知。所有这三种酶都催化潜在有害的N-羟基化化合物的还原，并且从药物设计的角度来看，对该领域有兴趣。本计画将应用电化学方法快速鉴定酵素底物与抑制剂。钼酶遍布所有生命形式，这项研究的结果包括对参与药物代谢的新兴酶类的统一理解。