Synthesis of stimuli-responsive star polymers for controlled drug delivery

该项目旨在通过可控自由基聚合技术制备适用于药物递送的新型星星聚合物。这种星星聚合物可以用于以受控的方式随时间在人体内释放药物，因此能够靶向特定部位，即肿瘤。释放特性受星星聚合物的结构和尺寸的影响，这可以容易地通过可控自由基聚合技术来改变。与类似结构的胶束相比，这些新型星形物由于其在注射时更高的稳定性而有望改善药物的释放动力学。

The project aims to prepare novel star polymers suitable for drug delivery via controlled radical polymerization techniques. Such star polymers can be employed to release drugs within the human body in a controlled manner over time and are thus able to target specific sites, i.e. a tumor. The release characterisitics are be influenced by the structure and the size of the star polymer, which can easily be altered via controlled radical polymerization techniques. These novel stars are expected to improve the release kinetics of the drug comparing to similar structured micelles due to their higher stability upon injection.