Multivalent drug delivery carrier for the targeted delivery of platinum anticancer agents to hepatocytes
Multivalent drug delivery carrier for the targeted delivery of platinum anticancer agents to hepatocytes
批准号:
DP0771155
负责人:
Prof Martina Stenzel
金额:
$18.95万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2007
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2007-01-01 至 2009-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Hepatocellular carcinoma (HCC) is often treated with chemotherapy using cytotoxic drugs. This systemic treatment results in the distribution of the drug throughout the body. Employing a polymer particle as a drug carrier for these drugs ensures a temporal control of the release and therefore supply of the drug within the body. By attaching carbohydrate moieties onto the surface of the polymer particle the drug carrier can specifically be recognized by cell receptors, thus allowing a targeted delivery of the drug to the desired area in the body. A range of carbohydrate-based drug carriers will be synthesized and tested towards their interaction with hepatocytes to allow optimisation of this drug carrier system.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Very small nanoparticles made to measure
-
批准号:FL200100124
-
项目类别:Australian Laureate Fellowships
-
资助金额:$240.27万
-
财政年份:2021
-
负责人:Prof Martina Stenzel
-
依托单位:
High Performance Solid State NMR Spectroscopy for Materials Research
-
批准号:LE200100136
-
项目类别:Linkage Infrastructure, Equipment and Facilities
-
资助金额:$73.35万
-
财政年份:2020
-
负责人:Prof Martina Stenzel
-
依托单位:
Virus-inspired nanoparticles based on polyion complex micelles
-
批准号:DP200101918
-
项目类别:Discovery Projects
-
资助金额:$30.7万
-
财政年份:2020
-
负责人:Prof Martina Stenzel
-
依托单位:
Bioactive Polymer Platelets
-
批准号:DP190102528
-
项目类别:Discovery Projects
-
资助金额:$20.19万
-
财政年份:2019
-
负责人:Prof Martina Stenzel
-
依托单位:
Polymeric nanoparticles for enzyme stabilisation
-
批准号:DP170101191
-
项目类别:Discovery Projects
-
资助金额:$23.29万
-
财政年份:2017
-
负责人:Prof Martina Stenzel
-
依托单位:
Origami with triblock copolymers
-
批准号:DP160101172
-
项目类别:Discovery Projects
-
资助金额:$29.52万
-
财政年份:2016
-
负责人:Prof Martina Stenzel
-
依托单位:
Polyion complex micelles as smart nano-sized drug carriers for proteins
-
批准号:DP140100240
-
项目类别:Discovery Projects
-
资助金额:$27.25万
-
财政年份:2014
-
负责人:Prof Martina Stenzel
-
依托单位:
Learning from nature: creating synthetic viruses using self-assembled structures with branched or dendritic glycopolymers on their surfaces
-
批准号:DP130101625
-
项目类别:Discovery Projects
-
资助金额:$25.58万
-
财政年份:2013
-
负责人:Prof Martina Stenzel
-
依托单位:
A platform for the efficient optimisation of drug delivery using cross-linked micelles and thioclick-chemistry toward better anti-cancer treatment
-
批准号:DP110102409
-
项目类别:Discovery Projects
-
资助金额:$31.67万
-
财政年份:2011
-
负责人:Prof Martina Stenzel
-
依托单位:
Core-shell nanoparticle from polymers with pendant cyclodextrins
-
批准号:DP1092661
-
项目类别:Discovery Projects
-
资助金额:$0.0万
-
财政年份:2010
-
负责人:Prof Martina Stenzel
-
依托单位:
Triggering the release of polymer bound platinum drugs
-
批准号:DP1092694
-
项目类别:Discovery Projects
-
资助金额:$22.99万
-
财政年份:2010
-
负责人:Prof Martina Stenzel
-
依托单位:
Platinum drugs containing core-shell nanoparticles
-
批准号:FT0991273
-
项目类别:ARC Future Fellowships
-
资助金额:$56.26万
-
财政年份:2009
-
负责人:Prof Martina Stenzel
-
依托单位:
Degradable hollow microspheres for liver cancer treatment
-
批准号:LP0882447
-
项目类别:Linkage Projects
-
资助金额:$21.37万
-
财政年份:2008
-
负责人:Prof Martina Stenzel
-
依托单位:
Novel Complex Architecture Polymers via a Combination of RAFT Chemistry and Pericyclic Reactions: Synthesis and Characterization
-
批准号:DP0769981
-
项目类别:Discovery Projects
-
资助金额:$24.63万
-
财政年份:2007
-
负责人:Prof Martina Stenzel
-
依托单位:
Synthesis of stimuli-responsive star polymers for controlled drug delivery
-
批准号:DP0450915
-
项目类别:Discovery Projects
-
资助金额:$16.36万
-
财政年份:2004
-
负责人:Prof Martina Stenzel
-
依托单位:
国内基金
海外基金
登录
查看更多内容
酶响应的中性粒细胞外泌体载药体系在眼眶骨缺损修复中的作用及机制研究
-
批准号:82371102
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:苏蕴
-
依托单位:
PfAP2-R介导的PfCRT转录调控在恶性疟原虫对喹啉类药物抗性中的作用及机制研究
-
批准号:82372275
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:刘耀宝
-
依托单位:
背根神经节中Mrgprd通过一种特异性lncRNA调控阿片类药物耐受的外周机制研究
-
批准号:82371224
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:马柯
-
依托单位:
不同功能基团的电中性Drug-Free纳米颗粒的构建及克服肿瘤耐药的研究
-
批准号:--
-
项目类别:青年科学基金项目
-
资助金额:30万元
-
批准年份:2022
-
负责人:杨胜彩
-
依托单位:
泛素结合酶UBE2S调控GPX4/SLC7A11影响肝癌细胞铁死亡的机制研究
-
批准号:32060159
-
项目类别:地区科学基金项目
-
资助金额:35.0万元
-
批准年份:2020
-
负责人:莫之婧
-
依托单位:
m6A识别蛋白YTHDF2促白血病细胞生长的研究
-
批准号:32070793
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:赵昀
-
依托单位:
TCF7L2突变介导SMAD7信号轴抑制KRAS突变型结直肠癌转移及耐药的分子机制研究
-
批准号:32000555
-
项目类别:青年科学基金项目
-
资助金额:24.0万元
-
批准年份:2020
-
负责人:徐亮
-
依托单位:
PRMT1-meFOXO1通路在低温常压等离子体诱导的三阴型乳腺癌细胞铁死亡中的作用机制研究
-
批准号:31900528
-
项目类别:青年科学基金项目
-
资助金额:19.0万元
-
批准年份:2019
-
负责人:王真
-
依托单位:
Drug-ADR-Pathway复合网络构建及ADR分子机制研究
-
批准号:61372188
-
项目类别:面上项目
-
资助金额:80.0万元
-
批准年份:2013
-
负责人:陈秀杰
-
依托单位:
IL-6自主分泌介导的B细胞来源淋巴造血系统肿瘤耐药的相关机制研究
-
批准号:81172109
-
项目类别:面上项目
-
资助金额:60.0万元
-
批准年份:2011
-
负责人:柳凤亭
-
依托单位: