Core-shell nanoparticle from polymers with pendant cyclodextrins

来自带有环糊精侧链的聚合物的核壳纳米颗粒

• 批准号: DP1092661
• 负责人: Prof Martina Stenzel
• 金额: --
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092661
• 关键词: Core; shell; nanoparticle; polymers; pendant

A better drug delivery system will be developed for the treatment of cancer with albendazole. These nanoparticles enhance the circulation time in the body, but also facilitate the delivery of the drug to the site of the tumour, which will increase the efficacy of the treatment. The nanoparticles are obtained by processing polymers with pendant cyclodextrin groups, which are a type of complex sugars. Aim of this work is the exploration of synthetic routes to generate nanoparticles. Tailoring the underpinning polymer structure of these nanoparticles will allow the optimisation of the release of albendazole from the drug carrier, thus improving cancer treatment.

为阿苯达唑治疗肿瘤提供了一种更好的给药系统。这些纳米颗粒增强了体内的循环时间，但也有助于将药物输送到肿瘤部位，这将提高治疗效果。纳米颗粒是通过加工具有环糊精侧基的聚合物获得的，环糊精侧基是一种复合糖。这项工作的目的是探索合成路线，以产生纳米粒子。定制这些纳米颗粒的基础聚合物结构将允许优化阿苯达唑从药物载体的释放，从而改善癌症治疗。