Virus-inspired nanoparticles based on polyion complex micelles

基于聚离子复合胶束的病毒纳米粒子

• 批准号: DP200101918
• 负责人: Prof Martina Stenzel
• 金额: $ 30.7万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101918
• 关键词: Virus; inspired; nanoparticles; based; polyion

Viruses are nature's nanoparticles that have evolved over millions of years into intelligent nanoparticles. The unique structure of viruses with their patchy surface has inspired the design of a new drug carrier by employing the power of polymers to self-organize. The project aims at mimicking nature’s nanoparticles with intelligent polymers while enabling the design of a platform that can entrap therapeutic proteins and enhance their delivery. The focus will be to gain in-depth understanding on the polymer self-assembly process in order to design a synthetically robust system that can be applied to various payloads. As a result, novel nanoparticles with virus-inspired structures for the delivery of therapeutic proteins will be created.

病毒是自然界的纳米粒子，经过数百万年的进化，成为智能纳米粒子。病毒的独特结构及其斑片状表面激发了利用聚合物自组织能力设计新型药物载体的灵感。该项目旨在用智能聚合物模拟自然界的纳米颗粒，同时设计一个可以捕获治疗性蛋白质并增强其递送的平台。重点将是深入了解聚合物自组装过程，以设计可应用于各种有效载荷的合成鲁棒系统。因此，将创建具有病毒启发结构的新型纳米颗粒，用于递送治疗性蛋白质。