Bioactive Polymer Platelets

生物活性聚合物血小板

• 批准号: DP190102528
• 负责人: Prof Martina Stenzel
• 金额: $ 20.19万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-06-26
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102528
• 关键词: Bioactive; Polymer; Platelets

This project aims to develop polymers that can be self-assembled into 2D structures. Most nanoparticles developed for drug delivery are spherical. However these are not always the most efficacious as theory suggest that non-spherical nanoparticles have longer circulation times. It is proposed that discoid morphologies may be advantageous as they tend to migrate to the vascular membrane and adhere more efficiently. The polymers developed by this project will be tailored towards bioactive and biocompatible material to create a drug delivery platform for more efficient disease treatment. The outcome will be better understanding on how polymer platelets can be obtained and how they compare in their biological activity with spherical nanoparticles.

该项目旨在开发可以自组装成2D结构的聚合物。大多数开发用于药物递送的纳米颗粒是球形的。然而，这些并不总是最有效的，因为理论表明非球形纳米颗粒具有更长的循环时间。有人提出，盘状形态可能是有利的，因为它们倾向于迁移到血管膜和更有效地粘附。该项目开发的聚合物将针对生物活性和生物相容性材料进行定制，以创建更有效的疾病治疗药物输送平台。其结果将是更好地了解如何获得聚合物血小板，以及它们如何与球形纳米颗粒的生物活性进行比较。