Triggering the release of polymer bound platinum drugs

铂类药物被发现是高效的抗癌药物。然而，它们的副作用限制了它们的应用。开发出了纳米颗粒，只要药物在血液中循环，就会将铂药物紧密结合在一起，但一旦药物到达肿瘤，就会释放药物。为了治疗前列腺癌，这种纳米颗粒将附着在靶向部分--一种单抗--上，该部分有助于有效地将其输送到前列腺癌细胞，但不会影响健康细胞。这项建议旨在开发合适的合成途径，通过使用合适的递送载体来加强癌症的治疗。

Platinum drugs are found to be highly efficient as anti-cancer drugs. Their side-effects however, limit their application. Nanoparticles are developed that bind the platinum drug tightly as long as the drug circulates in the blood stream, but releases the drug as soon as it reaches the tumour. To treat prostate cancer, the nanoparticle will be attached to a targeting moiety - a monoclonal antibody - that facilitates the effective delivery to the prostate cancer cells, but leaves healthy cells unaffected. This proposal aims to develop suitable synthetic pathway to enhance the treatment of cancer by using appropriate delivery vehicles.