Triggering the release of polymer bound platinum drugs

人们发现铂类药物作为抗癌药物具有很高的疗效。然而，它们的副作用限制了它们的应用。纳米颗粒被开发出来，只要药物在血液中循环，它们就会紧紧地结合铂药物，但一旦药物到达肿瘤就会释放药物。为了治疗前列腺癌，纳米颗粒将被附着在一个靶向部分——一种单克隆抗体——上，这种抗体促进了对前列腺癌细胞的有效递送，但不影响健康细胞。本提案旨在通过使用合适的递送载体，开发合适的合成途径来增强对癌症的治疗。

Platinum drugs are found to be highly efficient as anti-cancer drugs. Their side-effects however, limit their application. Nanoparticles are developed that bind the platinum drug tightly as long as the drug circulates in the blood stream, but releases the drug as soon as it reaches the tumour. To treat prostate cancer, the nanoparticle will be attached to a targeting moiety - a monoclonal antibody - that facilitates the effective delivery to the prostate cancer cells, but leaves healthy cells unaffected. This proposal aims to develop suitable synthetic pathway to enhance the treatment of cancer by using appropriate delivery vehicles.