Triggering the release of polymer bound platinum drugs

触发聚合物结合铂药物的释放

• 批准号: DP1092694
• 负责人: Prof Martina Stenzel
• 金额: $ 22.99万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1092694
• 关键词: Triggering; release; polymer; bound; platinum

Platinum drugs are found to be highly efficient as anti-cancer drugs. Their side-effects however, limit their application. Nanoparticles are developed that bind the platinum drug tightly as long as the drug circulates in the blood stream, but releases the drug as soon as it reaches the tumour. To treat prostate cancer, the nanoparticle will be attached to a targeting moiety - a monoclonal antibody - that facilitates the effective delivery to the prostate cancer cells, but leaves healthy cells unaffected. This proposal aims to develop suitable synthetic pathway to enhance the treatment of cancer by using appropriate delivery vehicles.

铂类药物被发现是高效的抗癌药物。然而，它们的副作用限制了它们的应用。纳米粒子的开发，紧紧结合铂药物，只要药物在血液中循环，但释放的药物，只要它到达肿瘤。为了治疗前列腺癌，纳米颗粒将连接到靶向部分-单克隆抗体-这有助于有效地递送到前列腺癌细胞，但不影响健康细胞。这项建议旨在开发合适的合成途径，以通过使用合适的运载工具来加强癌症的治疗。