Development of near-ultraviolet excitation autofluorescence apparatus with lesion imaging fluorescence automatic discrimination mechanism

我们于1991年研制了采用夜视装置的紫外激发自荧光照相装置。在激发波长410nm处识别出680 ~ 690nm和630nm的口腔癌特异荧光光谱。因此，我们用毛细管电泳法分析了该荧光物质的组成。结果我们发现了一些卟啉。每一种情况下都是同比例卟啉，是原卟啉和锌原卟啉。我们决定研制一种能够自动显示肿瘤浸润范围的仪器。本次新研制的病变成像荧光仪FLP-700，使其能够对口腔癌进行全身性的诊断，使荧光诊断成为可能。如果我们进一步增加病例，并能找到与临床信息/病理/后果/其他大多数背景因素的相关性，则认为在未来的癌症研究中有用。

We developed the UV-excited autofluorescence photographic apparatus which used night vision device at 1991. As a result it recognized specific fluorescence spectrum of 680-690nm and 630nm at excitation wave length 410nm in carcinoma of oral cavity.So we analyzed composition of this fluorescent substance by capillary electrophoresis. As a result we were able to detect some porphyrin. It was coproporphyrin by the each case and was protoporphyrin and was zinc protoporphyrin. And we have decided to develop the apparatus which can show invasion range of carcinoma clearly automatically. FLP-700 which was lesion imaging fluorescence apparatus developed afresh this time got possible to diagnose the whole of carcinoma of oral cavity, and fluorescence diagnosis was possible with non-aggression instantly.If we increase case furthermore and can find correlation with background factor of clinical information / pathology / consequence / the other most, it is thought that usefulness in a study of carcinoma in the future.