Molecular mechanism of D-serine for pathophysiology of schizophrenia
Molecular mechanism of D-serine for pathophysiology of schizophrenia
批准号:
22390220
负责人:
HASHIMOTO Kenji
金额:
$11.32万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
D-serine in the brain is known to be synthesized from serine racemase (SRR). In the methamphetamine model of schizophrenia, we found that methamphetamine-induced behavioral sensitization was not detected in the SRR knock-out mice. This study suggests that SRR plays a role in the development of behavioral sensitization by methamphetamine treatment.
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Comments to"The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia"
对“利培酮对 D-氨基酸氧化酶活性的影响作为治疗精神分裂症新作用机制的假设”的评论
DOI:
--
发表时间:
2010
期刊:
J.Psychopharmacol.
影响因子:
--
作者:
[Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N., Hatta T, K.Hashimoto]
通讯作者:
K.Hashimoto
The Handbook of Behavior, Diet and Nutrition
行为、饮食和营养手册
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[鈴木勝昭, 森則夫, Miyake N, K.Hashimoto]
通讯作者:
K.Hashimoto
DOI:
10.1371/journal.pone.0062438
发表时间:
2013
期刊:
PloS one
影响因子:
3.7
作者:
[Hagiwara H, Iyo M, Hashimoto K]
通讯作者:
Hashimoto K
DOI:
10.1111/j.1472-8206.2012.01045.x
发表时间:
2013-10-01
期刊:
FUNDAMENTAL & CLINICAL PHARMACOLOGY
影响因子:
2.9
作者:
[Horio, Mao, Fujita, Yuko, Hashimoto, Kenji]
通讯作者:
Hashimoto, Kenji
Levels of D-serine in the brain and periphery organs of serine racemase (Srr) knock-out mice
丝氨酸消旋酶(Srr)敲除小鼠大脑和周围器官中 D-丝氨酸水平
DOI:
--
发表时间:
2011
期刊:
Neurochemistry International
影响因子:
4.2
作者:
[Horio M, et al.]
通讯作者:
et al.
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