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Molecular mechanism of D-serine for pathophysiology of schizophrenia

Molecular mechanism of D-serine for pathophysiology of schizophrenia
D-丝氨酸在精神分裂症病理生理学中的分子机制
批准号:
22390220
负责人:
HASHIMOTO Kenji
金额:
$11.32万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
D-serine in the brain is known to be synthesized from serine racemase (SRR). In the methamphetamine model of schizophrenia, we found that methamphetamine-induced behavioral sensitization was not detected in the SRR knock-out mice. This study suggests that SRR plays a role in the development of behavioral sensitization by methamphetamine treatment.
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Comments to"The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia"
对“利培酮对 D-氨基酸氧化酶活性的影响作为治疗精神分裂症新作用机制的假设”的评论
DOI: --
发表时间: 2010
期刊: J.Psychopharmacol.
影响因子: --
作者: [Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N., Hatta T, K.Hashimoto]
通讯作者: K.Hashimoto
The Handbook of Behavior, Diet and Nutrition
行为、饮食和营养手册
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [鈴木勝昭, 森則夫, Miyake N, K.Hashimoto]
通讯作者: K.Hashimoto
DOI: 10.1371/journal.pone.0062438
发表时间: 2013
期刊: PloS one
影响因子: 3.7
作者: [Hagiwara H, Iyo M, Hashimoto K]
通讯作者: Hashimoto K
DOI: 10.1111/j.1472-8206.2012.01045.x
发表时间: 2013-10-01
期刊: FUNDAMENTAL & CLINICAL PHARMACOLOGY
影响因子: 2.9
作者: [Horio, Mao, Fujita, Yuko, Hashimoto, Kenji]
通讯作者: Hashimoto, Kenji
13
    Robot Design Incorporating Cartoon Expressions
    • 批准号:
      19K22880
    • 项目类别:
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额:
      $4.16万
    • 财政年份:
      2019
    • 负责人:
      HASHIMOTO Kenji
    • 依托单位:
    Laughter Detector and Laughter Stimuli Using Robot Technology Towards Physical and Mental Health Enhancement
    • 批准号:
      26560387
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2014
    • 负责人:
      HASHIMOTO Kenji
    • 依托单位:
    Study of synthesis and metabolism of D-serine in the brain
    • 批准号:
      23659557
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.08万
    • 财政年份:
      2011
    • 负责人:
      HASHIMOTO Kenji
    • 依托单位:
    Quantitative Sociological Analysis on Transformation processes of Japanese Society from prewar to postwar.
    海外基金