Study of synthesis and metabolism of D-serine in the brain
Study of synthesis and metabolism of D-serine in the brain
批准号:
23659557
负责人:
HASHIMOTO Kenji
金额:
$2.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
D-serine in the brain is known to be synthesized from serine racemase (SRR). In this study, we found that levels of D-aspartic acid I the forebrain of SRR knock-out (KO) mice was significantly lower than those of wild type mice. Furthermore, the enzymatic activity of D-aspartate oxidase (DDO) in the forebrain of SRR-KO mice was not changed. It is unlikely that DDO activity plays a role in the findings of this study.
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D-サイクロセリンは、脳においてD-セリンのプロドラッグか?
D-环丝氨酸是大脑中D-丝氨酸的前药吗?
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[堀尾菜央, 森寿, 橋本謙二]
通讯作者:
橋本謙二
(2013) Is D-cycloserine a prodrug forD-serine in the brain? Biol.
(2013) D-环丝氨酸是大脑中 D-丝氨酸的前药吗?
DOI:
--
发表时间:
2012
期刊:
Psychiatry
影响因子:
2.4
作者:
[Horio, M., Mori, H., and Hashimoto, K.]
通讯作者:
K.
(2011) Levels of D-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice.
(2011) 丝氨酸消旋酶 (Srr) 敲除小鼠大脑和外周器官中的 D-丝氨酸水平。
DOI:
--
发表时间:
2011
期刊:
Neurochem. Int.
影响因子:
--
作者:
[Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K.]
通讯作者:
K.
(2013) Decreased levels of D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice.
(2013) 丝氨酸消旋酶 (Srr) 敲除小鼠前脑中 D-天冬氨酸水平降低。
DOI:
--
发表时间:
2013
期刊:
Neurochem. Int.
影响因子:
--
作者:
[Horio, M., Ishima, T., Fujita, Y., Inoue, R., Mori, H., and Hashimoto, K.]
通讯作者:
K.
Levels of D-serine in the brain and periphery.
大脑和外周的 D-丝氨酸水平。
DOI:
--
发表时间:
2011
期刊:
Neurochemistry International
影响因子:
4.2
作者:
[Takeichi T, Sugiura K, et al., Horio M et al]
通讯作者:
Horio M et al
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