Study on the body effects of arsenic, indium and antimony as the semiconductive materials

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InAs is partially dissociated in vivo to form inorganic arsenic and indium. The principal metabolite of arsenic in the urine of hamsters was DMA. Indium was shown to specifically accumulate in the kidney and liver. but the concentration of arsenic was low. These results suggested a possible relationship between the metabolism and toxicity of InAs. InAs proved to be an arsenic compound of low toxicity, with an sc LD_<50> of 32.5 g/kg in mice. Indium accumulation in the liver, however, produced chronic toxic effects. Plasma biochemistries showed marked, consistent and statistically significant increases in the activities of GOT, GPT, gamma-GTP, LAP and LDH associated with indium deposition. Blood ALAD activity was inhibited by InAs or arsenic exposure. The results suggest that the enzymes in the heme pathway may have utility as markers of exposure/toxicity for these agents. The finding that urinary inorganic arsenic, DMA and inorganic arsenic in hair are greater than indium concentrations way serve as a sensitive biological indicator for InAs exposure.