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Studies on Protective Effects of Breast Feeding Against Rotavirus Infection in Infants.

母乳喂养对婴儿轮状病毒感染的保护作用研究。

基本信息

批准号：
02670244
负责人：
SODA Kenji
金额：
$ 1.15万
依托单位：
Yokohama City University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

项目摘要

Human rotavirus(HRV, Wa-strain)specific IgG antibodies in maternal(N=194)and cord serum(N=291)and HRV specific IgA antibodies in colostrum(K=304)were measured by ELISA to elucidate the protective effect of breast-feeding against diarrhea in infants. And we studied the morbidity of "winter gastroenteritis" in infants using the questionnaires on the infant's history of diarrhea and the period of breast feeding. The results were summarized as follows :Levels of HRY antibodies by parity.Positive rates of HRY antibodies in maternal serum and colostrum were almost similar. 93.0% and 91.3% respectively. The distribution of antibody levels in maternal sera of primiparas showed the peak at 20 GEU of titer, while the peak was seen at 60 GEU for mdltiparas. Higher titer. . Levels were also observed in colostra of multiparas than those of primiparas. Mean levels of antibodies to HRY in niaternal and cord sera and colostra of second-paras and multiparas were significantly higher than those of primi … More paras.Mean levels of HRV-specific-immunoglobulin classes were significantly higher in maternal sera and colostra of multiparas within 2 years after delivery than those of primiparas. However, mean levels of antibodies of multiparas with 4 years and more interval of delivery were similar to those of primiparas. These results suggest that mother's HRY antibodies might be increased by re-infection with IIRV from their children.Incidence rates of "winter gastroenteritis" in infants.Percentages of the infants fed with breast-milk and formula-milk were 36 % and 8 I, respectively. Fifty-six percent of the infants received mixed feeding. Of the 1588 infants, 224(14.4%)were affected with winter gastroenteritis. The morbidity of "winter gastroenteritis" before I year old in infants received with formula-milk alone or mixed feeding were significantly higher than that of infants with long period(over 6 months)breast-feeding.Most of mothers possessed antirotaviral antibodies in their colostra which were transferred to their infants by breast feeding. The present findings suggested that long period breast-feeding(over 6 months)was effective against HRY infection in infants. Less

采用ELISA法测定母体(N=194)和脐带血清(N=291)中人轮状病毒(HRV、Wa株)特异性IgG抗体以及初乳中HRV特异性IgA抗体(K=304)，以阐明母乳喂养对婴儿腹泻的保护作用。并通过对婴儿腹泻病史和母乳喂养时间的调查问卷，研究了婴儿“冬季胃肠炎”的发病情况。结果如下：胎次HRY抗体水平。母血清和初乳中HRY抗体阳性率几乎相似。分别为 93.0% 和 91.3%。初产妇母体血清中抗体水平的分布在20GEU滴度处出现峰值，而中产妇则在60GEU处出现峰值。滴度更高。。在经产妇初乳中也观察到该水平高于初产妇。第二产妇和经产妇的初产妇、脐带血清和初乳中 HRY 抗体的平均水平显着高于初产妇。产后 2 年内，经产妇的母体血清和初乳中 HRV 特异性免疫球蛋白类别的平均水平显着高于初产妇。然而，分娩间隔4年及以上的经产妇的平均抗体水平与初产妇相似。这些结果表明，母亲的HRY抗体可能因孩子再次感染IIRV而增加。婴儿“冬季胃肠炎”的发病率。母乳和配方奶喂养的婴儿比例分别为36%和8%。百分之五十六的婴儿接受混合喂养。 1588名婴儿中，224名（14.4%）患有冬季胃肠炎。单独或混合喂养婴儿1岁前“冬季胃肠炎”发病率明显高于长期（6个月以上）母乳喂养的婴儿。大多数母亲初乳中含有抗轮状病毒抗体，这些抗体通过母乳喂养传染给婴儿。目前的研究结果表明，长期母乳喂养（超过6个月）可有效预防婴儿HRY感染。较少的