Sero-epidemiological Study of Herpes Simplex Virus

点击翻译按钮获取中文摘要

A sensitive and reproducible micro-method to assay neutralizing antibodies against herpes simples virus(HSV) was established for analyzing antibody prevalence of HSV in normal population and in medical staffs.The results obtained by assaying 490 normal serum samples and 544 sera of medical personnel were summarized as follows:1. Antibody positive rate to HSV in 10-30 years-old population was low when compared with those of former reports carried out in 1962, 1973, and 1974.2. Concerning medical personnel, antibody prevalence was apparently low in doctors compared with that of controls in all age groups, but that of nursing staffs was slightly higher in general and this tendency was remarkable in a group aged 20-24 years.3. Eighteen-months follow-up was carried out in 177 nurses taking samples 2 or 3 times 6 to 12 months apart. Seroconversion was observed only in the group aged 20-29 years, and the conversion rate(3.4 %) was significantly higher than that of control population calculated from the value of sero-positive rate.These data indicate that young medical personnel, especially nurse, might be identified as one of risk groups of HSV infection as a result of lowered prevalence of antibody in a young adult population.