Studies of Experimental Oral Tumors Produced by Heterocyclic Amines in the Broiled Food

近年来，从氨基酸的热裂解物和熟食中分离出许多致突变物质。这些诱变剂是芳香杂环胺，Trp-P-2、Glu-P-1、MeIQ、MeIQx和IQ是其中的5种。在这个项目中，进行了四个实验。在第一个实验中，仓鼠的舌头用Trp-P-2或Glu-P-1处理16周，然后舌头受伤。这些舌头没有显示任何明显的上皮发育不良。在第二个实验中，用Trp-P-2或MeIQ处理4周并伴有双重创伤的仓鼠的大部分舌头显示上皮发育不良。在第三个实验中，用Trp-P-2或MelQx或IQ处理4周并结合双重创伤的仓鼠的舌头经常显示上皮发育不良。实验四，将Glu-P-1应用于大鼠牙龈伤口，引起上皮-结缔组织连接处，特别是基底层的明显超微结构变化。

Recently, many mutagenic compounds have been isolated from pyrolysates of amino acids and cooked foods. These mutagens are aromatic heterocyclic amines, and Trp-P-2, Glu-P-1, MeIQ, MeIQx and IQ are five of them. In this project, four experiments were performed. In the first experiment, the tongues of the hamsters were treated with Trp-P-2 or Glu-P-1 for 16 weeks, and then the tongues were wounded. These tongues did not show any marked epithelial dysplasias. In the second experiment, most of the tongues of the hamsters which were treated with Trp-P-2 or MeIQ for 4 weeks together with double woundings, showed epithelial dysplasias. In the third experiment, the tongues of the hamsters which were treated with Trp-P-2 or MelQx or IQ for 4 weeks in combination with double woundings, frequently showed epithelial dysplasias. In the forth experiment, the application of Glu-P-1 to the gingival wound in rats induced the marked ultrastructural changes in the epithelium-connective tissue junction, particularly the basal lamina.