Studies of Experimental Oral Tumors Produced by Heterocyclic Amines in the Broiled Food

烧烤食品中杂环胺产生实验性口腔肿瘤的研究

• 批准号: 02670820
• 负责人: KAMEYAMA Yoichiro
• 金额: $ 1.41万
• 依托单位: Aichi-Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670820/
• 关键词: animal; tongue; gingiva; wound; heterocyclic amines

Recently, many mutagenic compounds have been isolated from pyrolysates of amino acids and cooked foods. These mutagens are aromatic heterocyclic amines, and Trp-P-2, Glu-P-1, MeIQ, MeIQx and IQ are five of them. In this project, four experiments were performed. In the first experiment, the tongues of the hamsters were treated with Trp-P-2 or Glu-P-1 for 16 weeks, and then the tongues were wounded. These tongues did not show any marked epithelial dysplasias. In the second experiment, most of the tongues of the hamsters which were treated with Trp-P-2 or MeIQ for 4 weeks together with double woundings, showed epithelial dysplasias. In the third experiment, the tongues of the hamsters which were treated with Trp-P-2 or MelQx or IQ for 4 weeks in combination with double woundings, frequently showed epithelial dysplasias. In the forth experiment, the application of Glu-P-1 to the gingival wound in rats induced the marked ultrastructural changes in the epithelium-connective tissue junction, particularly the basal lamina.

近年来，从氨基酸的热裂解物和熟食中分离出许多致突变物质。这些诱变剂是芳香杂环胺，Trp-P-2、Glu-P-1、MeIQ、MeIQx和IQ是其中的5种。在这个项目中，进行了四个实验。在第一个实验中，仓鼠的舌头用Trp-P-2或Glu-P-1处理16周，然后舌头受伤。这些舌头没有显示任何明显的上皮发育不良。在第二个实验中，用Trp-P-2或MeIQ处理4周并伴有双重创伤的仓鼠的大部分舌头显示上皮发育不良。在第三个实验中，用Trp-P-2或MelQx或IQ处理4周并结合双重创伤的仓鼠的舌头经常显示上皮发育不良。实验四，将Glu-P-1应用于大鼠牙龈伤口，引起上皮-结缔组织连接处，特别是基底层的明显超微结构变化。

项目成果

武井 道則,藤田 雄敏,亀山 洋一郎他4名: "ラット歯肉の創傷治癒におよぼすGluーPー1(2ーaminoー6ーmethyl dipyridoー[1,2ーa:3',2'ーd]imidazole)の影響" 日本口腔科学会雑誌. (1992)

Michinori Takei、Yutoshi Fujita、Yoichiro Kameyama 和其他 4 人：“Glu-P-1(2-氨基-6-甲基联吡啶-[1,2-a:3,2-d”)对大鼠牙龈伤口愈合的影响]咪唑）》日本口腔医学会杂志（1992）

Fujita, K., Itatsu, K., Suzuki, J., Sato, E., Maeda, H. and Kameyama, Y.: "Histological study on experimental dysplasia using aromatic heterocyclic amines (Trp-P-2, MeIQx, IQ)" J. Jpn. Stomatol. Soc.40. 499-506 (1991)

Fujita, K.、Itatsu, K.、Suzuki, J.、Sato, E.、Maeda, H. 和 Kameyama, Y.：“使用芳香杂环胺（Trp-P-2、MeIQx、IQ）对实验性发育不良进行组织学研究

Takesue, M., Fujita, K., Nonobe, K., Hara, M., Sato, E., Maeda, H. and Kameyama, Y.: "Effect of Glu-P-1 (2-amino-6-methyl dipyrido-[1, 2-a : 3', 2'-d]imidazole) on wound healing of the rat gingiva." J. Jpn. Stomatol. Soc.

Takesue, M.、Fujita, K.、Nonobe, K.、Hara, M.、Sato, E.、Maeda, H. 和 Kameyama, Y.：“Glu-P-1 (2-amino-6-

藤田 雄敏,板津 厚治,鈴木 純二,佐藤 恵美子,前田 初彦,亀山 洋一郎: "芳香族ヘテロサイクリックアミン(TrpーPー2,MeIQx,IQ)による実験的上皮性異形成の病理学的研究" 日本口腔科学会雑誌. 40. 499-506 (1991)

Yutoshi Fujita、Atsuji Itatsu、Junji Suzuki、Emiko Sato、Hatsuhiko Maeda、Yoichiro Kameyama：“芳香族杂环胺（Trp-P-2、MeIQx、IQ）诱导的实验性上皮发育不良的病理学研究”日本口腔医学会杂志 40。 499-506（1991）

武居 道則,藤田 雄敏,亀山 洋一郎他4名: "ラット歯肉の創傷治癒におよぼすGluーPー1(2ーaminoー6ーmethyl dipyridoー[1,2ーa:3',2'ーd]imidazole)の影響" 日本口腔科学会雑誌. (1992)

Michinori Takei、Yutoshi Fujita、Yoichiro Kameyama 和其他 4 人：“Glu-P-1(2-氨基-6-甲基联吡啶-[1,2-a:3,2-d”)对大鼠牙龈伤口愈合的影响]咪唑）》日本口腔医学会杂志（1992）