Studies on the mechanisms of persistent infection and reactivation of animal viruses
动物病毒持续感染和再激活机制研究
基本信息
- 批准号:03404014
- 负责人:
- 金额:$ 17.92万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (A)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1993
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In persistent infection, virus can hidden in body and escape from immunological prcsurc, in spite of the presence of immunity. However, the virus is sometimes reactivated to produce diseases in host. Following results were obtained.The feline immunodeficiency virus (FIV) antigens were observed in many follicular dandritic cells (FDCs) and sparsely in small lymphocytes of paracortical area in the lymph nodes of cats inoculated with FIVFeline calicivirus causes persistent infection in feline T-cells in vitroFeline herpcsvirus type 1(FHV-1) activated FIV long terminal repeat(LTR). The target sites in LTR appeared to be ATF binding site and TATA elementThe nucleotide sequence of FHV-1 immuediate early (IE) gene and its flanking sequences were identified as a ICP4 homologue of HSV-1. The sequence had ahomology of 35-50% with ICP4 homologue of other a herpesvirusThe HSV-1, PRV and EHV-1 ICP4 homologues can transrepress the FIV, while the FHV-1 ICP4 homologue has no effect in CRFK and Felis catus whole fetus 4(fcwf-4) cells. The FHV-1 ICP4 homologue can stimulate the HIV LTR in CPFK cells but not in fcwr-4 cells. The others have or little effect in CRFK and fcwf-4 cells All the ICP4 homologues can transactivate the FIV and HIV LTRs in SW480 cells.
在持续感染中,尽管存在免疫力,病毒仍能隐藏在体内,逃避免疫过程。然而,病毒有时会被重新激活,在宿主中产生疾病。结果表明:猫免疫缺陷病毒(FIV)抗原主要存在于猫淋巴结的滤泡性丹状细胞(FDC)和皮质旁区的小淋巴细胞中,在体外猫T细胞中FHV-1可引起持续感染。LTR的靶位点为ATF结合位点和TATA元件。FHV-1免疫早期(IE)基因及其侧翼序列与HSV-1的ICP 4同源。HSV-1、PRV和EHV-1的ICP 4同源物对FIV有反式抑制作用,而FHV-1的ICP 4同源物对CRFK和Felis卡图斯whole fetus 4(fcwf-4)细胞无反式抑制作用。FHV-1 ICP 4同源物可以刺激CPFK细胞中的HIV LTR,但不能刺激fcwr-4细胞中的HIV LTR。其他的对CRFK和fcwf-4细胞有或无作用。ICP 4同源物对SW 480细胞中的FIV和HIV LTR有反式激活作用。
项目成果
期刊论文数量(15)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Horimoto,T.et al.: "Heterogeneity of feline herpesvirus type 1 strains." Archives of Virology. 126. 283-292 (1992)
Horimoto,T.et al.:“猫疱疹病毒 1 型毒株的异质性。”
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
Tokunaga,K.et al: "Altered cell tropism and cytopathicity of feline immunodeficiency viruses to two different feline CD4ーpositive,CDー8ーnegative cell line" J.Virol.(1992)
Tokunaga, K. 等人:“猫免疫缺陷病毒对两种不同的猫 CD4 阳性、CD 8 阴性细胞系的细胞向性和细胞病变性发生改变”J.Virol.(1992)
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- 影响因子:0
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Miyazawa,T.,et al.: "Biological nature of feline immunodeficiency virus." Journal of Veterinary Medical Science. 55. 519-526 (1993)
Miyazawa,T.,et al.:“猫免疫缺陷病毒的生物学性质。”
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- 影响因子:0
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Kawaguchi,Y.et al.: "Sequences within the feline immunodeficiency virus long terminal repeat that regulate gene expression and respond to activation by feline herpesvirus type 1." Virogy. 190. 465-468 (1992)
Kawaguchi, Y. 等人:“猫免疫缺陷病毒长末端重复序列内调节基因表达并对 1 型猫疱疹病毒激活作出反应。”
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- 影响因子:0
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Xuan,X.et.al.: "Glycoprotein-Specific immune respondes in canine herpesvirus infection." Archeves of Virology. 122. 359-365 (1992)
Xu,X.et.al.:“犬疱疹病毒感染中糖蛋白特异性免疫反应。”
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- 影响因子:0
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MIKAMI Takeshi其他文献
MIKAMI Takeshi的其他文献
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{{ truncateString('MIKAMI Takeshi', 18)}}的其他基金
The role of gangliosides for neuroregeneration in ischemic stroke
神经节苷脂在缺血性中风神经再生中的作用
- 批准号:
22591593 - 财政年份:2010
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$ 17.92万 - 项目类别:
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Risk Surveillanceand Individualization :Risk Society and the Individual
风险监控与个体化:风险社会与个人
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21530497 - 财政年份:2009
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Risk society and moral: New sociological perspective which cuts the relation between the individual and the society.
风险社会与道德:切断个人与社会关系的新社会学视角
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17530364 - 财政年份:2006
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$ 17.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
NPO system and its consciousness of norm and the sense of public
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13610202 - 财政年份:2001
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$ 17.92万 - 项目类别:
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Control of toxoplasmosis by inducing Th1 helper cells
通过诱导 Th1 辅助细胞控制弓形体病
- 批准号:
11306019 - 财政年份:1999
- 资助金额:
$ 17.92万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Studies on control of animal protozoan diseases by recombinant herpesvirus vector vaccines
重组疱疹病毒载体疫苗防治动物原虫病的研究
- 批准号:
11356009 - 财政年份:1999
- 资助金额:
$ 17.92万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Identity and Social Character in the Information Society.
信息社会中的身份和社会特征。
- 批准号:
09610179 - 财政年份:1997
- 资助金额:
$ 17.92万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular and Immunological Studies on Feline Immunodeficiency Virus
猫免疫缺陷病毒的分子和免疫学研究
- 批准号:
07306014 - 财政年份:1995
- 资助金额:
$ 17.92万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
DEVELOPMENT OF POLYVALENT RECOMBINANT VACCINES FOR CATS.
猫多价重组疫苗的开发。
- 批准号:
07556069 - 财政年份:1995
- 资助金额:
$ 17.92万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Studies on the mechanisms of persistent infection and reactivation of animal viruses.
动物病毒持续感染和再激活机制研究。
- 批准号:
06404015 - 财政年份:1994
- 资助金额:
$ 17.92万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
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