The role of gangliosides for neuroregeneration in ischemic stroke

神经节苷脂在缺血性中风神经再生中的作用

• 批准号: 22591593
• 负责人: MIKAMI Takeshi
• 金额: $ 2.5万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591593/
• 关键词: 脳神経疾患; 糖脂質; ガングリオシド; 脳虚血; 神経再生; 脳梗塞; もやもや病; 脳動静脈奇形; phosphodiesterase; CT; MRI; NMR; 間葉系幹細胞移植

High performance liquid chromatography (HPLC) was performed to detect the difference of glycolipid between the normal and the infarcted brains, however, the sensitivity was not enough to detect the differences. The microarray analysis indidated that the expression of phosphodiesterase 10A (PDE10A) was high in the infarted brain compared to the normal brain. We performed immunohistochemical analysis with anti-PDE10A antibody. The results indicated that the PDE10A is associated with neural regeneration. Thus, we will perform furth er studies forneuroregeneration with these results.

进行高性能液相色谱（HPLC），以检测正常和梗塞大脑之间糖脂的差异，但是，灵敏度不足以检测差异。微阵列分析迹象表明，与正常脑相比，在基础大脑中，磷酸二酯酶10a（PDE10A）的表达很高。我们用抗PDE10A抗体进行了免疫组织化学分析。结果表明PDE10A与神经再生有关。因此，我们将通过这些结果进行促进的研究。

项目成果

Arterial Spin-Labeling Magnetic Resonance Imaging After Revascularization of Moyamoya Disease

• DOI: 10.1016/j.jstrokecerebrovasdis.2012.05.010
• 发表时间: 2013-08-01
• 期刊: JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
• 影响因子: 2.5
• 作者: Sugino, Toshiya;Mikami, Takeshi;Mikuni, Nobuhiro
• 通讯作者: Mikuni, Nobuhiro

Bumping phenomenon during continuous coagulation with bipolar forceps

双极钳连续电凝过程中的碰撞现象

• 发表时间: 2012
• 期刊: Neurol Med Chir (Tokyo)
• 作者: Suzuki J;Sasaki M;Harada K;BandoM;Kataoka Y;Onodera R;Mikami T;Wanibuchi M;Mikuni N;Kocsis JD;Honmou O;Sugino T;三上毅;Mikami T;Sugino T;Mikami T;Mikami T
• 通讯作者: Mikami T

Multidetector Row CTによるもやもや病の診断

使用多排排 CT 诊断烟雾病

• 发表时间: 2011
• 作者: 杉野寿哉;三上毅;飯星智史;小柳泉;宝金清博
• 通讯作者: 宝金清博

Area Detector CTによるperfusion CTの使用経験

使用灌注 CT 和区域探测器 CT 的经验

• 发表时间: 2011
• 作者: 三上毅;飯星智史;杉野寿哉;三國信啓
• 通讯作者: 三國信啓

Diagnosis of Moyamoya Disease on Magnetic Resonance Imaging: Are Flow Voids in the Basal Ganglia an Essential Criterion for Definitive Diagnosis?

• DOI: 10.1016/j.jstrokecerebrovasdis.2012.07.010
• 发表时间: 2013-08-01
• 期刊: JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
• 影响因子: 2.5
• 作者: Mikami, Takeshi;Sugino, Toshiya;Mikuni, Nobuhiro
• 通讯作者: Mikuni, Nobuhiro