Population Genetic Study of Mongolians

蒙古族群体遗传学研究

• 批准号: 04041033
• 负责人: OMOTO Keiichi
• 金额: $ 3.84万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04041033/
• 关键词: Mongolians; Population Genetics; Anthropology; Blood Groups; Viral Epidemiology; Genetic Polymorphism; Horse; Mitochondrial DNA

This research project aims at obtaining data of blood genetic markers such as blood groups and protein types as well as DNA types of Mongolians in order to clarify the phylogenetic relationships of Mongolians among other Asian peoples. Also planned are epidemiological studies of viruses as HTLV, HBV and HCV and genetic studies of horses and other domestic animals.The results so far obtained are as follows.(1) Blood samples of 194 Mongolians, most of which are from Khalha ethnic group, and 150 horses as well as 30 camels were collected during the field study.(2) Eight blood groups systems were examined and the results indicated that Mongolians are nor so closely related to Japanese as Koreans.(3) As to mitochondrial DNA, frequencies of HincII morphs and Asian specific 9 base deletion were determined on Mongolians. The HincII morph 6 which has been reported only in American Indians was found with remarkably high frequency (21.4%). The frequency of 9 base deletion was 5.9%, which is much … More lower than in Japanese (16%). A rare case of insertion in 3 out of 136 Mongolians.(4) HTLV positive sera was not found, in accordance with the theory that this virus occurs in descendants of proto-Mongoloids, but not in neo-Mongoloids. HBV had frequency of about 10%, while very high incidence of HCV (40%)was noted. This finding partially explains the high incidence of hepatitis and hepatic cancer in Mongolia.(5) Adult lactose absorption test was carried out on 20 human subjects, and one subject was found to be the absorber. This result is in accordance with the theory that among livestock breeders frequency of absorbers is high while among agriculturists it is very low.(6) Blood samples were collected from 150 horses and 30 camels. Antibody tests for equine influenza viruses A/eq/Miami/1/63 and A/eq/prague/1/56 showed that all the horses ahd camels tested were negative careers. Also, no animal was positive for antibody of bird influenza virus A/duck/Ukraine/1/63, which caused a severe prevalence of influenza among horses of northern China during 1989-1990. Less

该研究项目旨在获得蒙古人的血型和蛋白质类型以及DNA类型等血液遗传标记数据，以澄清蒙古人与其他亚洲民族的系统发育关系。还计划对HTLV、HBV和HCV等病毒进行流行病学研究，并对马和其他家畜进行遗传学研究。(1)在实地研究期间，收集了194名蒙古人的血液样本，其中大部分来自Khalha族，以及150匹马和30头骆驼。(2)8个血型系统的检测结果表明，蒙古族与日本人的亲缘关系不如朝鲜族。(3)至于线粒体DNA，HincII变体和亚洲人特有的9个碱基缺失的频率在蒙古人身上进行了测定。仅在美洲印第安人中报道的HincII变体6以非常高的频率（21.4%）被发现。9个碱基缺失的频率为5.9%， ...更多信息 低于日本人（16%）。136名蒙古人中有3名罕见的插入病例。(4)未发现HTLV阳性血清，这与该病毒存在于原始蒙古人种后代中而不存在于新蒙古人种中的理论一致。HBV的频率约为10%，而HCV的发病率非常高（40%）。这一发现部分解释了蒙古国肝炎和肝癌发病率高的原因。(5)对20名人类受试者进行成人乳糖吸收试验，发现一名受试者是吸收者。这一结果与以下理论是一致的：在家畜饲养者中，吸收器的频率很高，而在农业家中，吸收器的频率很低。(6)采集了150匹马和30头骆驼的血样。对马流感病毒A/eq/迈阿密/1/63和A/eq/布拉格/1/56进行抗体检测，结果表明所检测的马和骆驼均为阴性。此外，没有动物对禽流感病毒A/duck/Ukraine/1/63抗体呈阳性，导致1989-1990年中国北方马流感严重流行。少

项目成果

Saitou,N.,Tokunaga,K.,and Omoto,K.: "Society for the Study of Human Biology Symposium Series 33:Isolation and Migration" Cambridge University Press,Cambridge, (1992)

Saitou, N.、Tokunaga, K. 和 Omoto, K.：“人类生物学研究学会研讨会系列 33：隔离与迁移”剑桥大学出版社，剑桥，（1992 年）

Omoto, K., et al.: "Population Genetic Study in Hainan Island, China. I.Distribution of Blood Genetic Markers" Anthropol. Sci.101(1). 1-24 (1993)

Omoto, K., et al.：“中国海南岛的人口遗传学研究。I.血液遗传标记的分布”Anthropol。

Batsuuri, J., et al.: "Absence of human T-lymphotropic retrovirus type-1 in different populations of Monfolia." Scand. J. Infect. Dis.

Batsuuri, J. 等人：“Monfolia 不同种群中不存在 1 型人类 T 淋巴细胞逆转录病毒。”

Ishida,T.,et al.: "A seroepidemiological study of HTLV-1 infection in Nepal." Scand.J.Infect.Dis.24. 399-400 (1992)

Ishida,T.,et al.：“尼泊尔 HTLV-1 感染的血清流行病学研究。”

Batsuuri,J.,et al.: "Absence of human T-lymphotropic retrovirus type-1 in different popularions of Mongolia." Scand.J.Infect.Dis.

Batsuuri, J., et al.：“蒙古不同流行地区不存在 1 型人类 T 淋巴细胞逆转录病毒。”