Defense mechanism of insect (Sarcophaga peregrina)
Defense mechanism of insect (Sarcophaga peregrina)
批准号:
04102006
负责人:
NATORI Shunji
金额:
$112.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Specially Promoted Research
财政年份:
1992
资助国家:
日本
项目状态:
已结题
起止时间:
1992 至 1994
中文摘要
昆虫已经发展出一种独特的防御系统来抵御各种外界刺激,如微生物感染和整体损伤。我们一直在研究肉蝇(Sarcophaga peregrina)各种防御蛋白。这些蛋白质包括一种凝集素和几种抗菌蛋白质。通过这些研究,我们得出结论,这些防御蛋白有两个重要的新方面。一个是单一防御蛋白可能在防御和发育中至少扮演两个角色。昆虫可能会灵活地以多种方式使用一种防御蛋白质。另一个有趣的方面是昆虫防御系统的系统发育意义。昆虫的防御系统可能是哺乳动物防御系统的原型。除了这两个重要方面外,我们还获得了昆虫免疫学的许多重要发现。这些发现大多已经发表。
英文摘要
Insect have developed a unique defense system against various outside stimuli such as microbial infection and integmental injury. We have been studying various defense proteins of Sarcophaga peregrina (the flesh fly). These proteins include a lectin and several antibacterial proteins. Throughout these studies, we came to the conclusion that there are two important novel aspects of these defense proteins. One is that a single defense protein probably plays at least two roles in defense and development. Insects probably have the flexibility to use one defense protein in multiple ways. The other interesting aspect is the phylogenetical significance of the insect defense system. Insect defense system is possibly a prototype of the mammalian defense system. Except these two important aspects, we obtained various important findings on insect immnity. Most of these findings have been published.
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T.Nakanishi, A.Nakano, K.Nomura, K.Sekimizu and S.Natori: "Purification, gene cloning, and gene disruption of the transcription elongation factor S-II in Saccharomyces cerevisiae." J.Biol.Chem.267. 13200-13204 (1992)
T.Nakanishi、A.Nakano、K.Nomura、K.Sekimizu 和 S.Natori:“酿酒酵母转录延伸因子 S-II 的纯化、基因克隆和基因破坏。”
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N.Takahashi, S.Kurata and S.Natori: "Molecular cloning of cDNA for the 29kDa proteinase participating in decomposition of the larval fat body during metamorphosis of Sarcophaga peregrina (flesh fly)." FEBS Letts.334. 153-157 (1993)
N.Takahashi、S.Kurata 和 S.Natori:“29kDa 蛋白酶的 cDNA 分子克隆,该蛋白酶参与游隼(肉蝇)变态过程中幼虫脂肪体的分解。”
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Masafumi Shimoda: "Inhibition of the Ca^<2+>-activated K^+-channel by sapecin B、an insect antibacterial protein" FEBS Letts.339. 59-62 (1994)
Masafumi Shimoda:“昆虫抗菌蛋白 sapecin B 对 Ca^2+-激活的 K^+-通道的抑制”FEBS Letts.339 (1994)。
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Katsushige Yamada: "Characterization of the antibacterial peptide derived from sapecin B、anantibacterial protein of Sarcophaga peregrina(flesh fly)" Biochem.J.298. 623-628 (1994)
Katsushige Yamada:“来自 sapecin B 的抗菌肽的表征,sapecin B 是游隼(肉蝇)的抗菌蛋白”Biochem.J.298(1994)。
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Chalk R: "Purification of an insect defensin from the mosquito, Ades aeqypti" Insect Biochem. Mol. Biol.24. 403-410 (1994)
Chalk R:“从蚊子 Ades aeqypti 中纯化昆虫防御素”Insect Biochem。
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共 93 条
Analysis of the receptor of an antibacterial peptide on human neutrophils.
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批准号:08458192
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.74万
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财政年份:1996
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负责人:NATORI Shunji
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依托单位:
Identification of the active domain of insect antibacterial proteins and production of new antibacterial peptides.
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批准号:07557152
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$6.02万
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财政年份:1995
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负责人:NATORI Shunji
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依托单位:
formation of transqenic plant resistant to bacterial infection containing insect antibacterial protein genes
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批准号:01890004
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$14.78万
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财政年份:1989
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负责人:NATORI Shunji
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依托单位:
Studies on the Dual Functions of Defense Molecules
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批准号:63440080
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$19.33万
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财政年份:1988
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负责人:NATORI Shunji
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依托单位:
Analysis of Sarcophaga lectin receptor on the surface of murine macrophages
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批准号:61480458
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.84万
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财政年份:1986
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负责人:NATORI Shunji
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依托单位:
Development of convenient method to diagnose tumor by use of Sarcophaga lectin
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批准号:61870095
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$5.76万
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财政年份:1986
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负责人:NATORI Shunji
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依托单位:
Development of antibacterial drugs based on insect antibacteria proteins
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批准号:58870113
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$4.29万
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财政年份:1983
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负责人:NATORI Shunji
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依托单位:
海外基金