Developing macrophage-based technologies for tissue regeneration

开发基于巨噬细胞的组织再生技术

• 批准号: LP210200908
• 负责人: Prof Peter Currie
• 金额: $ 61.71万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-03 至 2026-03-02
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP210200908
• 关键词: Developing; macrophage; based; technologies; tissue

Different tissues show distinct regenerative capacities with an organism and across the phylogeny. What underlies this diversity in regenerative ability at cellular and molecular level is far from clear. Building on foundational discoveries in zebrafish, this study seeks to determine if this capacity could, in part, be explained through the properties of a component of the innate immune system, the macrophage, which preliminary data shows generates a transient pro-regenerative muscle stem cell niche in zebrafish. This study will determine if macrophage subtypes acts to coordinate regeneration in other tissues and systems and if a programable pro-regenerative cell can be made in vitro that stimulate regeneration in different settings.

不同的组织表现出不同的再生能力与生物体和跨越系统发育。在细胞和分子水平上，这种再生能力的多样性背后的原因尚不清楚。基于斑马鱼的基础发现，本研究试图确定这种能力是否可以部分地通过先天免疫系统组成部分巨噬细胞的特性来解释，初步数据显示巨噬细胞在斑马鱼中产生了短暂的促再生肌肉干细胞生态位。这项研究将确定巨噬细胞亚型是否在其他组织和系统中协调再生，以及是否可以在体外制造可编程的促再生细胞来刺激不同环境下的再生。