Developing macrophage-based technologies for tissue regeneration
Developing macrophage-based technologies for tissue regeneration
批准号:
LP210200908
负责人:
Prof Peter Currie
金额:
$61.71万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Linkage Projects
财政年份:
2023
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2023-03-03 至 2026-03-02
中文摘要
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英文摘要
Different tissues show distinct regenerative capacities with an organism and across the phylogeny. What underlies this diversity in regenerative ability at cellular and molecular level is far from clear. Building on foundational discoveries in zebrafish, this study seeks to determine if this capacity could, in part, be explained through the properties of a component of the innate immune system, the macrophage, which preliminary data shows generates a transient pro-regenerative muscle stem cell niche in zebrafish. This study will determine if macrophage subtypes acts to coordinate regeneration in other tissues and systems and if a programable pro-regenerative cell can be made in vitro that stimulate regeneration in different settings.
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会议论文
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Fins to Limbs: Investigating the Evolution of complex Limb Musculature
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How limbs evolved from fins: the role of somite cells
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批准号:DP190102204
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项目类别:Discovery Projects
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资助金额:$26.67万
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财政年份:2019
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负责人:Prof Peter Currie
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依托单位:
Genetic basis for skeletal muscle formation and regeneration in development and disease
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批准号:nhmrc : 1136567
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项目类别:Research Fellowships
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负责人:Prof Peter Currie
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依托单位:
Defining the molecular regulation of muscle stem cell action during organ growth
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批准号:nhmrc : GNT1139253
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项目类别:Project Grants
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资助金额:$73.83万
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财政年份:2018
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负责人:Prof Peter Currie
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依托单位:
Genetic basis for skeletal muscle formation and regeneration in development and disease
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依托单位:
Defining the molecular regulation of muscle stem cell action during organ growth
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负责人:Prof Peter Currie
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依托单位:
Mechanisms of muscle stem cell action in injury and disease.
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依托单位:
Evolution of the dermomyotome in vertebrates
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依托单位:
Mechanisms of muscle stem cell action in injury and disease.
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批准号:nhmrc : GNT1104190
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资助金额:$81.26万
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依托单位:
Molecular mechanisms that generate muscle cell type diversity.
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批准号:DP150103820
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项目类别:Discovery Projects
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资助金额:$22.66万
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财政年份:2015
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依托单位:
Genetic basis for skeletal muscle formation in development and disease.
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资助金额:$50.13万
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财政年份:2013
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负责人:Prof Peter Currie
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依托单位:
Modelling Laminin mediated adhesion and congenital muscular dystrophy in Zebrafish
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资助金额:$39.08万
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财政年份:2013
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负责人:Prof Peter Currie
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依托单位:
Molecular mechanisms that generate and activate muscle stem cells during growth and disease.
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批准号:nhmrc : 1045468
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项目类别:Project Grants
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资助金额:$39.75万
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财政年份:2013
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负责人:Prof Peter Currie
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依托单位:
Generating a targeted mutation resource in zebrafish
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项目类别:Linkage Projects
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资助金额:$38.11万
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财政年份:2012
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负责人:Prof Peter Currie
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依托单位:
The role of scube gene function in hedgehog signal transduction
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财政年份:2012
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负责人:Prof Peter Currie
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依托单位:
Genetic and molecular basis of appendicular muscle formation
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项目类别:Discovery Projects
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资助金额:$19.68万
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财政年份:2011
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负责人:Prof Peter Currie
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依托单位:
The development and evolution of the pelvic girdle in basal gnathostomes
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批准号:DP1096002
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项目类别:Discovery Projects
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资助金额:$19.85万
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财政年份:2010
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依托单位:
Molecular and cellular basis for muscle regeneration in zebrafish.
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项目类别:NHMRC Project Grants
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资助金额:$36.08万
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财政年份:2008
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负责人:Prof Peter Currie
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依托单位:
国内基金
海外基金
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