The role of scube gene function in hedgehog signal transduction
The role of scube gene function in hedgehog signal transduction
批准号:
nhmrc : 1027862
负责人:
Prof Peter Currie
金额:
$36.49万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2015-12-31
中文摘要
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英文摘要
The Hedgehog signaling pathway controls development of the early embryo and is one of the most common pathways mutated in human cancer. Through the use of zebrafish genetics we have identified a new component of this pathway, Scube2 that controls the ability of cells to be activated by Hedgehog signaling. We plan to further investigate how this occurs and design therapeutically relevant peptides based on the scube2 protein that could act as inhibitors of the pathway
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