Mechanisms of muscle stem cell action in injury and disease.

肌肉干细胞在损伤和疾病中的作用机制。

• 批准号: nhmrc : 1104190
• 负责人: Prof Peter Currie
• 金额: $ 55.9万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-muscle-stem-injury-disease/662729
• 关键词: Mechanisms; muscle; stem; cell; action

How do stem cells work in an organ or tissue to effect repair? Skeletal muscle is one of the few tissues that possesses the ability to regenerate after injury or disease but we understand very little about the processes that govern stem cell activation and the biology of self renewal, the mysterious process by which stem cell populations replicate themselves. Our zebrafish system will allow us to examine these questions directly in living muscle.

干细胞如何在器官或组织中发挥作用以实现修复？骨骼肌是为数不多的在受伤或疾病后具有再生能力的组织之一，但我们对管理干细胞激活的过程和自我更新的生物学知之甚少，这是干细胞群体自我复制的神秘过程。我们的斑马鱼系统将允许我们直接在活体肌肉中研究这些问题。