Genetic basis for skeletal muscle formation and regeneration in development and disease

发育和疾病中骨骼肌形成和再生的遗传基础

• 批准号: nhmrc : 1136567
• 负责人: Prof Peter Currie
• 金额: $ 59.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-basis-skeletal-development-disease/1318474
• 关键词: Genetic; basis; skeletal; muscle; formation

How does muscle grow and repair after injury or disease? This basic question in the focus of the research in this fellowship. Specific cells are put aside during development to generate the growth and provide stem cells required for regeneration. Using the advantages of the zebrafish system I will record the action of different stem cell populations during growth and disease. I will define the genes required for stem cell action and utilize this knowledge to create new therapeutic pathways.

肌肉在受伤或疾病后是如何生长和修复的？这一基本问题是本次研究会研究的重点。特定的细胞在发育过程中被搁置，以产生生长并提供再生所需的干细胞。利用斑马鱼系统的优势，我将记录不同干细胞群体在生长和疾病期间的行为。我将定义干细胞活动所需的基因，并利用这些知识创造新的治疗途径。